National Cancer Institute Thesaurus

Last uploaded: September 30, 2019
Preferred Name

Anisindione

Synonyms

Anisindione

2-p-Anisyl-1,3-indandione

Miradon

Unidone

1,3-Indandione, 2-(p-methoxyphenyl)-

ANISINDIONE

Definitions

A synthetic indanedione anticoagulant. Anisindione interferes with the vitamin K-dependent hepatic synthesis of active clotting factors by inhibiting the reduction of vitamin K. This leads to an inhibition of gamma-carboxylation of glutamic acid residues to gamma-carboxyglutamic acid in clotting factors II, VII, IX and X. The consequential effects of this inhibition include a reduced activity of these clotting factors and prolonged blood clotting time.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47398

CAS_Registry

117-37-3

CHEBI_ID

CHEBI:133809

Chemical_Formula

C16H12O3

code

C47398

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A synthetic indanedione anticoagulant. Anisindione interferes with the vitamin K-dependent hepatic synthesis of active clotting factors by inhibiting the reduction of vitamin K. This leads to an inhibition of gamma-carboxylation of glutamic acid residues to gamma-carboxyglutamic acid in clotting factors II, VII, IX and X. The consequential effects of this inhibition include a reduced activity of these clotting factors and prolonged blood clotting time.

FDA_UNII_Code

S747T1ERAJ

FULL_SYN

Anisindione

2-p-Anisyl-1,3-indandione

Miradon

Unidone

1,3-Indandione, 2-(p-methoxyphenyl)-

ANISINDIONE

label

Anisindione

Legacy_Concept_Name

Anisindione

Preferred_Name

Anisindione

prefixIRI

ncit:C47398

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0051919

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C263

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http://www.drugbank.ca/drugs/DB01125 FTC LOOM
http://purl.bioontology.org/ontology/MESH/C010679 MESH LOOM
http://purl.obolibrary.org/obo/DRON_00010087 DRON LOOM
http://purl.obolibrary.org/obo/DRON_00010087 DRON LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147108 NDFRT LOOM
http://purl.bioontology.org/ontology/VANDF/4018805 VANDF LOOM
http://purl.obolibrary.org/obo/CHEBI_133809 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_133809 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_133809 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_133809 CHEBI LOOM
http://purl.bioontology.org/ontology/SNMI/C-A6510 SNMI LOOM
http://purl.bioontology.org/ontology/RXNORM/17941 RXNORM LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/38122009 SNOMEDCT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C010679 RH-MESH LOOM