loading...| Preferred Name |
Aminophylline |
|
| Synonyms |
Ammophyllin Truphylline AMINOPHYLLINE 1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-, compound with 1,2-Ethanediamine(2:1) Theophyline Ethylenediamine Phyllocontin Aminophylline |
|
| Definitions |
A methylxanthine and derivative of theophylline. Aminophylline relaxes smooth muscles, particularly bronchial muscles. This xanthine most likely exerts its effect by inhibiting cAMP or cGMP phosphodiesterases, thereby increasing levels of the second messenger cAMP or cGMP intracellularly. Other mode of actions include an adenosine antagonistic effect on the activity of CD4 lymphocytes and mediator release from mast cells thereby decreasing lung sensitivity to allergens and other substances that cause inflammation. Aminophylline also acts as a CNS stimulant and exerts a positive chronotropic and inotropic effect on the heart. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47393 |
|
| CAS_Registry |
317-34-0 |
|
| Chemical_Formula |
2C7H8N4O2.C2H8N2 |
|
| code |
C47393 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
|
| Contributing_Source |
CTRP FDA |
|
| DEFINITION |
A methylxanthine and derivative of theophylline. Aminophylline relaxes smooth muscles, particularly bronchial muscles. This xanthine most likely exerts its effect by inhibiting cAMP or cGMP phosphodiesterases, thereby increasing levels of the second messenger cAMP or cGMP intracellularly. Other mode of actions include an adenosine antagonistic effect on the activity of CD4 lymphocytes and mediator release from mast cells thereby decreasing lung sensitivity to allergens and other substances that cause inflammation. Aminophylline also acts as a CNS stimulant and exerts a positive chronotropic and inotropic effect on the heart. |
|
| Display_Name |
Aminophylline |
|
| FDA_UNII_Code |
27Y3KJK423 |
|
| FULL_SYN |
Ammophyllin Truphylline AMINOPHYLLINE 1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-, compound with 1,2-Ethanediamine(2:1) Theophyline Ethylenediamine Phyllocontin Aminophylline |
|
| label |
Aminophylline |
|
| Legacy Concept Name |
Aminophylline |
|
| NCI_Drug_Dictionary_ID |
682624 |
|
| NSC Number |
7919 |
|
| PDQ_Closed_Trial_Search_ID |
682624 |
|
| PDQ_Open_Trial_Search_ID |
682624 |
|
| Preferred_Name |
Aminophylline |
|
| prefixIRI |
Thesaurus:C47393 |
|
| Semantic_Type |
Pharmacologic Substance |
|
| UMLS_CUI |
C0722625 |
|
| subClassOf |