loading...| Preferred Name |
Domperidone |
|
| Synonyms |
DOMPERIDONE Domperidone KW 5338 Motilium R 33,812 |
|
| Definitions |
A peripheral-specific antagonist of the dopamine receptor D2 (D2R), with antiemetic, gastrokinetic and galactagogue activities. Following administration, domperidone binds to D2R expressed by peripheral neurons; this inhibits dopamine binding and D2R-mediated signaling. Inhibition of peripheral D2R signaling prevents or relieves various gastrointestinal (GI) symptoms, such as nausea and vomiting, and may help relief reflux and symptoms of a variety of other upper GI disorders. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C454 |
|
| CAS_Registry |
57808-66-9 |
|
| CHEBI_ID |
CHEBI:31515 |
|
| Chemical_Formula |
C22H24ClN5O2 |
|
| code |
C454 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 |
|
| Contributing_Source |
CTRP FDA HemOnc |
|
| DEFINITION |
A peripheral-specific antagonist of the dopamine receptor D2 (D2R), with antiemetic, gastrokinetic and galactagogue activities. Following administration, domperidone binds to D2R expressed by peripheral neurons; this inhibits dopamine binding and D2R-mediated signaling. Inhibition of peripheral D2R signaling prevents or relieves various gastrointestinal (GI) symptoms, such as nausea and vomiting, and may help relief reflux and symptoms of a variety of other upper GI disorders. |
|
| Display_Name |
Domperidone |
|
| FDA_UNII_Code |
5587267Z69 |
|
| FULL_SYN |
DOMPERIDONE Domperidone KW 5338 Motilium R 33,812 |
|
| label |
Domperidone |
|
| Legacy Concept Name |
Domperidone |
|
| NCI_Drug_Dictionary_ID |
40071 |
|
| NSC Number |
299589 |
|
| PDQ_Closed_Trial_Search_ID |
40071 |
|
| PDQ_Open_Trial_Search_ID |
40071 |
|
| Preferred_Name |
Domperidone |
|
| prefixIRI |
Thesaurus:C454 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0013015 |
|
| subClassOf |