loading...| Preferred Name |
Diethylstilbestrol |
|
| Synonyms |
Diethylstilbenediol Diethylstilbestrol Stilbestrol 4,4'-Dihydroxy-.alpha., .beta.-diethylstilbene Stilboestroform Stilboestrol Oestromensyl DIETHYLSTILBESTROL diethylstilbestrol (DES) .alpha., .alpha.'-Diethylstilbenediol diethylstilbestrol Diethylstilboestrol (E)-4,4'-(1,2-diethyl-1,2-ethenediyl)bisphenol 3, 4-Bis(p-hydroxyphenyl)-3-hexene 3,4-Bis(p-hydroxyphenyl)-3-hexene Trans-bis-(hydroxy-4-phenyl)-3,4 hexene-3 4,4'-Dihydroxy-alpha,beta-diethylstilbene Alpha,alpha'-diethylstilbenediol 3-Hexene,3,4-bis(p-hydroxyphenyl)- Oestromenin Synthoestrin Stilboefral Neo-Oestronol I Diethylstilbestrolum Oestrogenine Acnestrol Antigestil Apstil Boestrol Bufon Cyren A DES Diastyl Distilbene Domestrol Estrobene Estromenin Estrosyn Fonatol Grafestrol Makarol Microest Milestrol Oestromon Palestrol Serral Sexocretin Sibol Stilbetin Stilkap Synestrin Vagestrol |
|
| Definitions |
A synthetic, nonsteroidal form of estrogen. A well-known teratogen and carcinogen, diethylstilbestrol inhibits the hypothalamic-pituitary-gonadal axis, thereby blocking the testicular synthesis of testosterone, lowering plasma testosterone, and inducing a chemical castration. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C433 |
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| Accepted_Therapeutic_Use_For |
Breast cancer; Prostate cancer |
|
| ALT_DEFINITION |
A synthetic form of the hormone estrogen that was prescribed to pregnant women between about 1940 and 1971 because it was thought to prevent miscarriages. Diethylstilbestrol may increase the risk of uterine, ovarian, or breast cancer in women who took it. It also has been linked to an increased risk of clear cell carcinoma of the vagina or cervix in daughters exposed to diethylstilbestrol before birth. |
|
| CAS_Registry |
56-53-1 |
|
| CHEBI_ID |
CHEBI:41922 |
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| Chemical_Formula |
C18H20O2 |
|
| code |
C433 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C192234 |
|
| Contributing_Source |
FDA HemOnc OORO |
|
| DEFINITION |
A synthetic, nonsteroidal form of estrogen. A well-known teratogen and carcinogen, diethylstilbestrol inhibits the hypothalamic-pituitary-gonadal axis, thereby blocking the testicular synthesis of testosterone, lowering plasma testosterone, and inducing a chemical castration. |
|
| FDA_UNII_Code |
731DCA35BT |
|
| FULL_SYN |
Diethylstilbenediol Diethylstilbestrol Stilbestrol 4,4'-Dihydroxy-.alpha., .beta.-diethylstilbene Stilboestroform Stilboestrol Oestromensyl DIETHYLSTILBESTROL diethylstilbestrol (DES) .alpha., .alpha.'-Diethylstilbenediol diethylstilbestrol Diethylstilboestrol (E)-4,4'-(1,2-diethyl-1,2-ethenediyl)bisphenol 3, 4-Bis(p-hydroxyphenyl)-3-hexene 3,4-Bis(p-hydroxyphenyl)-3-hexene Trans-bis-(hydroxy-4-phenyl)-3,4 hexene-3 4,4'-Dihydroxy-alpha,beta-diethylstilbene Alpha,alpha'-diethylstilbenediol 3-Hexene,3,4-bis(p-hydroxyphenyl)- Oestromenin Synthoestrin Stilboefral Neo-Oestronol I Diethylstilbestrolum Oestrogenine Acnestrol Antigestil Apstil Boestrol Bufon Cyren A DES Diastyl Distilbene Domestrol Estrobene Estromenin Estrosyn Fonatol Grafestrol Makarol Microest Milestrol Oestromon Palestrol Serral Sexocretin Sibol Stilbetin Stilkap Synestrin Vagestrol |
|
| label |
Diethylstilbestrol |
|
| Legacy Concept Name |
Diethylstilbestrol |
|
| NCI_Drug_Dictionary_ID |
43081 |
|
| NSC Number |
3070 |
|
| PDQ_Closed_Trial_Search_ID |
43081 |
|
| PDQ_Open_Trial_Search_ID |
43081 |
|
| Preferred_Name |
Diethylstilbestrol |
|
| prefixIRI |
Thesaurus:C433 |
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| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0012203 |
|
| subClassOf |