loading...| Preferred Name |
Zalcitabine |
|
| Synonyms |
2',3'-Dideoxycytidine Zalcitabine ZALCITABINE Dideoxycytidine Hivid ddC |
|
| Definitions |
A synthetic dideoxynucleoside. After intracellular phosphorylation to its active metabolite, zalcitabine preferentially inhibits the gamma form of DNA polymerase present in tumor cell mitochondria, resulting in the inhibition of tumor cell mitochondrial DNA replication and tumor cell death. (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C430 |
|
| CAS_Registry |
7481-89-2 |
|
| CHEBI_ID |
CHEBI:10101 |
|
| Chemical_Formula |
C9H13N3O3 |
|
| code |
C430 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
|
| Contributing_Source |
FDA GDC |
|
| DEFINITION |
A synthetic dideoxynucleoside. After intracellular phosphorylation to its active metabolite, zalcitabine preferentially inhibits the gamma form of DNA polymerase present in tumor cell mitochondria, resulting in the inhibition of tumor cell mitochondrial DNA replication and tumor cell death. (NCI04) |
|
| FDA_UNII_Code |
6L3XT8CB3I |
|
| FULL_SYN |
2',3'-Dideoxycytidine Zalcitabine ZALCITABINE Dideoxycytidine Hivid ddC |
|
| Is_Value_For_GDC_Property | ||
| label |
Zalcitabine |
|
| Legacy Concept Name |
Zalcitabine |
|
| Maps_To |
Zalcitabine |
|
| NCI_Drug_Dictionary_ID |
40349 |
|
| NSC Number |
606170 |
|
| PDQ_Closed_Trial_Search_ID |
40349 |
|
| PDQ_Open_Trial_Search_ID |
40349 |
|
| Preferred_Name |
Zalcitabine |
|
| prefixIRI |
Thesaurus:C430 |
|
| Semantic_Type |
Pharmacologic Substance Nucleic Acid, Nucleoside, or Nucleotide |
|
| UMLS_CUI |
C0012132 |
|
| subClassOf |