National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Deferoxamine

Synonyms

Desferoxamine B

DEFEROXAMINE

Desferrioxamine

1-Amino-6,17-dihydroxy-7,10,18,21-tetraoxo-27-(n-acetylhydroxylamino)-6,11,17,22-tetraazaheptaeicosane

Deferoxamine

Desferrioxamine B

N'-[5-[[4-[[5-(Acetylhydroxyamino)pentyl]amino]-1,4-dioxobutyl]hydroxyamino]pentyl]-N-(5-aminopentyl)-N-hydroxybutanediamide

deferoxamine

N-[5-[3-[(5-Aminopentyl)hydroxycarbamoyl]propionamido]pentyl]-3-[[5-(N-hydroxyacetamido)pentyl]carbamoyl]propionohydroxamic Acid

DFO-B

Definitions

An iron-chelating agent that binds free iron in a stable complex, preventing it from engaging in chemical reactions. Deferoxamine chelates iron from intra-lysosomal ferritin and siderin forming ferrioxamine, a water-soluble chelate excreted by the kidneys and in the feces via the bile. This agent does not readily bind iron from transferrin, hemoglobin, myoglobin or cytochrome. (NCI04)

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C416

ALT_DEFINITION

An iron-chelating agent that removes iron from tumors by inhibiting DNA synthesis and causing cancer cell death. It is used in conjunction with other anticancer agents in pediatric neuroblastoma therapy.

CAS_Registry

70-51-9

CHEBI_ID

CHEBI:4356

Chemical_Formula

C25H48N6O8

code

C416

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177537

Contributing_Source

CTRP

FDA

GDC

HemOnc

DEFINITION

An iron-chelating agent that binds free iron in a stable complex, preventing it from engaging in chemical reactions. Deferoxamine chelates iron from intra-lysosomal ferritin and siderin forming ferrioxamine, a water-soluble chelate excreted by the kidneys and in the feces via the bile. This agent does not readily bind iron from transferrin, hemoglobin, myoglobin or cytochrome. (NCI04)

Display_Name

Deferoxamine

FDA_UNII_Code

J06Y7MXW4D

FULL_SYN

Desferoxamine B

DEFEROXAMINE

Desferrioxamine

1-Amino-6,17-dihydroxy-7,10,18,21-tetraoxo-27-(n-acetylhydroxylamino)-6,11,17,22-tetraazaheptaeicosane

Deferoxamine

Desferrioxamine B

N'-[5-[[4-[[5-(Acetylhydroxyamino)pentyl]amino]-1,4-dioxobutyl]hydroxyamino]pentyl]-N-(5-aminopentyl)-N-hydroxybutanediamide

deferoxamine

N-[5-[3-[(5-Aminopentyl)hydroxycarbamoyl]propionamido]pentyl]-3-[[5-(N-hydroxyacetamido)pentyl]carbamoyl]propionohydroxamic Acid

DFO-B

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1972

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C417

Has_Target

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C598

Is_Value_For_GDC_Property

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1909

label

Deferoxamine

Legacy Concept Name

Deferoxamine

Maps_To

Deferoxamine

NSC Number

527604

Preferred_Name

Deferoxamine

prefixIRI

Thesaurus:C416

Semantic_Type

Organic Chemical

Pharmacologic Substance

UMLS_CUI

C0011145

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C360

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http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C416 ENM SAME_URI
http://purl.bioontology.org/ontology/SNMI/C-B8010 SNMI LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/372825006 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147797 NDFRT LOOM
http://purl.obolibrary.org/obo/MESH_D003676 BERO LOOM
http://purl.bioontology.org/ontology/LNC/LP70623-1 LOINC LOOM
http://www.phoc.org.cn/pmo/class/PMO_00016185 PMAPP-PMO LOOM
https://go.drugbank.com/drugs/DB00746 MDM LOOM
http://purl.bioontology.org/ontology/VANDF/4019705 VANDF LOOM
http://purl.obolibrary.org/obo/NCIT_C416 BERO LOOM
http://stirdf.jst.go.jp/id/200907070761791808 IOBC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D003676 RH-MESH LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#3658 OCHV LOOM
http://purl.bioontology.org/ontology/RXNORM/3131 RXNORM LOOM
http://purl.bioontology.org/ontology/CSP/1629-5423 CRISP LOOM
http://purl.obolibrary.org/obo/OMIT_0004959 OMIT LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000147797 ODAE LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.241.511.372.265 RH-MESH LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C416 ENM LOOM
http://purl.jp/bio/4/id/200906045835840930 IOBC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.092.570.394.265 RH-MESH LOOM
http://purl.bioontology.org/ontology/MESH/D003676 MESH LOOM
http://purl.obolibrary.org/obo/dinto_DB00746 DINTO LOOM
http://bmi.utah.edu/ontologies/hfontology/C0011145 HFO LOOM
http://purl.bioontology.org/ontology/ATC/V03AC01 ATC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0011145 OCHV LOOM