National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Adverse Reaction

Synonyms

adverse reaction

ADVERSE REACTION

Adverse Effect

Adverse Reaction

adverse effect

ADR

AR

Definitions

Any noxious and unintended response(s) to a medical product or procedure, for which a causal relationship with this product or procedure is at least a reasonable possibility i.e., the relationship cannot be ruled out.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C41332

ALT_DEFINITION

An unexpected medical problem that happens during treatment with a drug or other therapy. Adverse effects do not have to be caused by the drug or therapy, and they may be mild, moderate, or severe.

A response to a medicinal product, devices, or procedures, which is noxious and unintended. Response in this context means that a causal relationship between a medicinal product and an adverse event is at least a reasonable possibility. In the context of drug development, the term is used as a synonym of adverse drug reaction. (After ICH E2A)

code

C41332

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C54452

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61410

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C54599

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C67497

Contributing_Source

CDISC-GLOSS

FDA

DEFINITION

Any noxious and unintended response(s) to a medical product or procedure, for which a causal relationship with this product or procedure is at least a reasonable possibility i.e., the relationship cannot be ruled out.

DesignNote

WHO Technical Report 498 definition the post-marketing setting: A response to a drug which is noxious and unintended and which occurs at doses normally used in man for prophylaxis, diagnosis, or therapy of disease or for modification of physiological function.

The old term Side Effect is retired and should not be used.

FULL_SYN

adverse reaction

ADVERSE REACTION

Adverse Effect

Adverse Reaction

adverse effect

ADR

AR

label

Adverse Reaction

Legacy Concept Name

Adverse_Reaction

Preferred_Name

Adverse Reaction

prefixIRI

Thesaurus:C41332

Semantic_Type

Finding

UMLS_CUI

C0559546

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C41331

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