loading...| Preferred Name |
Cyclosporine |
|
| Synonyms |
CYCLOSPORINE Cyclosporine Ciclosporin Cyclosporine Modified cyclosporine Cyclosporin Cyclosporin A Cyclosporine modified Cyclosporine non-modified 27-400 CsA CyA Gengraf Neoral OL 27-400 Sandimmune SangCya |
|
| Definitions |
A natural cyclic polypeptide immunosuppressant isolated from the fungus Beauveria nivea. The exact mechanism of action of cyclosporine is not known but may involve binding to the cellular protein cytophilin, resulting in inhibition of the enzyme calcineurin. This agent appears to specifically and reversibly inhibit immunocompetent lymphocytes in the G0-or G1-phase of the cell cycle. T-lymphocytes are preferentially inhibited with T-helper cells as the primary target. Cyclosporine also inhibits lymphokine production and release. (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C406 |
|
| Accepted_Therapeutic_Use_For |
Allogenic transplants; prophylaxis of organ rejection in bone marrow; kidney; liver and heart transplants; psoriasis; rheumatoid arthritis; various diseases that involve autoimmune response |
|
| ALT_DEFINITION |
A drug used to help reduce the risk of rejection of organ and bone marrow transplants by the body. It is also used in clinical trials to make cancer cells more sensitive to anticancer drugs. |
|
| CAS_Registry |
59865-13-3 |
|
| CHEBI_ID |
CHEBI:4031 |
|
| Chemical_Formula |
C62H111N11O12 |
|
| code |
C406 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 |
|
| Contributing_Source |
CTRP FDA GDC HemOnc |
|
| DEFINITION |
A natural cyclic polypeptide immunosuppressant isolated from the fungus Beauveria nivea. The exact mechanism of action of cyclosporine is not known but may involve binding to the cellular protein cytophilin, resulting in inhibition of the enzyme calcineurin. This agent appears to specifically and reversibly inhibit immunocompetent lymphocytes in the G0-or G1-phase of the cell cycle. T-lymphocytes are preferentially inhibited with T-helper cells as the primary target. Cyclosporine also inhibits lymphokine production and release. (NCI04) |
|
| Display_Name |
Cyclosporine |
|
| FDA_UNII_Code |
83HN0GTJ6D |
|
| FULL_SYN |
CYCLOSPORINE Cyclosporine Ciclosporin Cyclosporine Modified cyclosporine Cyclosporin Cyclosporin A Cyclosporine modified Cyclosporine non-modified 27-400 CsA CyA Gengraf Neoral OL 27-400 Sandimmune SangCya |
|
| Is_Value_For_GDC_Property | ||
| label |
Cyclosporine |
|
| Legacy Concept Name |
Cyclosporine |
|
| Maps_To |
Cyclosporine |
|
| NCI_Drug_Dictionary_ID |
39201 |
|
| NSC Number |
290193 |
|
| PDQ_Closed_Trial_Search_ID |
39201 |
|
| PDQ_Open_Trial_Search_ID |
39201 |
|
| Preferred_Name |
Cyclosporine |
|
| prefixIRI |
Thesaurus:C406 |
|
| Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance |
|
| UMLS_CUI |
C0010592 |
|
| subClassOf |