National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Cyclophosphamide

Synonyms

2-[di(chloroethyl)amino]-1-oxa-3-aza-2-phosphacyclohexane 2-oxide monohydrate

Syklofosfamid

(-)-Cyclophosphamide

2H-1,3,2-Oxazaphosphorine, 2-[bis(2-chloroethyl)amino]tetrahydro-, 2-oxide, monohydrate

Ciclofosfamida

N,N-bis(beta-chloroethyl)-N',O-propylenephosphoric acid ester diamide monohydrate

Cyclophosphamide Monohydrate

2-[bis(b-chloroethyl)amino]-1-oxa-3-aza-2-phosphacyclohexane-2-oxide monohydrate

CYCLOPHOSPHAMIDE

Cyclophosphamide

cyclophosphamide

Cyclophosphan

Cyclophospham

1-bis(2-chloroethyl)-amino-1-oxo-2-aza-5-oxaphosphoridin monohydrate

Cytophosphan

Cytophosphane

N,N-bis(2-chloroethyl)-N',O-propylenephosphoric acid ester diamide monohydrate

CP monohydrate

Cyclophosphamidum

Cycloblastin

Cycloblastine

Ciclofosfamide

N,N-bis(2-chloroethyl)-N'-(3-hydroxypropyl)phosphorodiamidic acid intramolecular ester monohydrate

bis(2-chloroethyl)phosphamide cyclic propanolamide ester monohydrate

N,N-bis(b-chloroethyl)-N',O-trimethylenephosphoric acid ester diamide monohydrate

Cyclophosphanum

N,N-bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide monohydrate

Cyclophosphamid monohydrate

N,N-bis(beta-chloroethyl)-N',O-trimethylenephosphoric acid ester diamide monohydrate

2-[bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide monohydrate

Bis(2-chloroethyl)phosphoramide cyclic propanolamide ester monohydrate

Cyclophosphane

Asta B 518

B-518

CTX

CYCLO-cell

Carloxan

Cicloxal

Clafen

Claphene

Cyclostin

Cyclostine

Cytoxan

Fosfaseron

Genoxal

Genuxal

Ledoxina

Mitoxan

Neosar

Revimmune

WR- 138719

WR-138719

Definitions

A synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities. In the liver, cyclophosphamide is converted to the active metabolites aldophosphamide and phosphoramide mustard, which bind to DNA, thereby inhibiting DNA replication and initiating cell death.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C405

Accepted_Therapeutic_Use_For

Breast cancer; Leukemias; Lupus nephritis; Lymphoma; Multiple myeloma; Neuroblastoma; Nephrotic syndrome; Ovarian cancer; Retinoblastoma; Acute Lymphoblastic Leukemia; Acute Myeloid Leukemia; Chronic Lymphocytic Leukemia; Chronic Myelogenous Leukemia

ALT_DEFINITION

A drug that is used to treat many types of cancer and is being studied in the treatment of other types of cancer. It is also used to treat some types of kidney disease in children. Cyclophosphamide attaches to DNA in cells and may kill cancer cells. It is a type of alkylating agent.

CAS_Registry

6055-19-2

CHEBI_ID

CHEBI:4026

Chemical_Formula

C7H15Cl2N2O2P.H2O

code

C405

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173234

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C186328

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C186327

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C174019

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177383

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177406

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C186341

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177537

Contributing_Source

CTRP

FDA

GDC

HemOnc

PCDC

DEFINITION

A synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities. In the liver, cyclophosphamide is converted to the active metabolites aldophosphamide and phosphoramide mustard, which bind to DNA, thereby inhibiting DNA replication and initiating cell death.

Display_Name

Cyclophosphamide

FDA_UNII_Code

8N3DW7272P

FULL_SYN

2-[di(chloroethyl)amino]-1-oxa-3-aza-2-phosphacyclohexane 2-oxide monohydrate

Syklofosfamid

(-)-Cyclophosphamide

2H-1,3,2-Oxazaphosphorine, 2-[bis(2-chloroethyl)amino]tetrahydro-, 2-oxide, monohydrate

Ciclofosfamida

N,N-bis(beta-chloroethyl)-N',O-propylenephosphoric acid ester diamide monohydrate

Cyclophosphamide Monohydrate

2-[bis(b-chloroethyl)amino]-1-oxa-3-aza-2-phosphacyclohexane-2-oxide monohydrate

CYCLOPHOSPHAMIDE

Cyclophosphamide

cyclophosphamide

Cyclophosphan

Cyclophospham

1-bis(2-chloroethyl)-amino-1-oxo-2-aza-5-oxaphosphoridin monohydrate

Cytophosphan

Cytophosphane

N,N-bis(2-chloroethyl)-N',O-propylenephosphoric acid ester diamide monohydrate

CP monohydrate

Cyclophosphamidum

Cycloblastin

Cycloblastine

Ciclofosfamide

N,N-bis(2-chloroethyl)-N'-(3-hydroxypropyl)phosphorodiamidic acid intramolecular ester monohydrate

bis(2-chloroethyl)phosphamide cyclic propanolamide ester monohydrate

N,N-bis(b-chloroethyl)-N',O-trimethylenephosphoric acid ester diamide monohydrate

Cyclophosphanum

N,N-bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide monohydrate

Cyclophosphamid monohydrate

N,N-bis(beta-chloroethyl)-N',O-trimethylenephosphoric acid ester diamide monohydrate

2-[bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide monohydrate

Bis(2-chloroethyl)phosphoramide cyclic propanolamide ester monohydrate

Cyclophosphane

Asta B 518

B-518

CTX

CYCLO-cell

Carloxan

Cicloxal

Clafen

Claphene

Cyclostin

Cyclostine

Cytoxan

Fosfaseron

Genoxal

Genuxal

Ledoxina

Mitoxan

Neosar

Revimmune

WR- 138719

WR-138719

Is_PCDC_AML_Authorized_Value_For_Variable

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C274

Is_PCDC_GCT_Authorized_Value_For_Variable

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C274

Is_Value_For_GDC_Property

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C574

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1909

label

Cyclophosphamide

Legacy Concept Name

Cyclophosphamide

Maps_To

Cyclophosphamide

NCI_Drug_Dictionary_ID

39748

NSC Number

26271

PDQ_Closed_Trial_Search_ID

39748

PDQ_Open_Trial_Search_ID

39748

Preferred_Name

Cyclophosphamide

prefixIRI

Thesaurus:C405

Semantic_Type

Organic Chemical

Pharmacologic Substance

UMLS_CUI

C0010583

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C574

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C697

Delete Subject Author Type Created
No notes to display
Create mapping

Delete Mapping To Ontology Source
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C405 ROO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_4027 OBA LOOM
http://purl.obolibrary.org/obo/XCO_0000825 XCO LOOM
http://www.co-ode.org/ontologies/galen#Cyclophosphamide GALEN LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C405 ROO LOOM
http://purl.bioontology.org/ontology/CSP/1371-8600 CRISP LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.455.526.728.650.730.243 RH-MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D003520 RH-MESH LOOM
http://purl.bioontology.org/ontology/LNC/LP70366-7 LOINC LOOM
http://scai.fraunhofer.de/MSOntology#Cyclophosphamide MSO LOOM
http://www.phoc.org.cn/pmo/class/PMO_00017036 PMAPP-PMO LOOM
http://purl.obolibrary.org/obo/CHEBI_4027 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_4027 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_4027 FIDEO LOOM
http://purl.obolibrary.org/obo/CHEBI_4027 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_4027 DOID LOOM
http://purl.obolibrary.org/obo/CHEBI_4027 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_4027 HHEAR LOOM
http://purl.obolibrary.org/obo/CHEBI_4027 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_4027 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_4027 OBA LOOM
http://purl.obolibrary.org/obo/CHEBI_4027 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_4027 NIFSTD LOOM
http://purl.obolibrary.org/obo/CHEBI_4027 GO-PLUS LOOM
http://purl.bioontology.org/ontology/SNMI/C-78070 SNMI LOOM
http://bmi.utah.edu/ontologies/peontology/C0010583 RAO LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#3529 OCHV LOOM
http://purl.bioontology.org/ontology/RXNORM/3002 RXNORM LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387420009 SNOMEDCT LOOM
http://purl.org/obo/owl/CHEBI#CHEBI_4027 NPO LOOM
https://github.com/sap218/ocimido/blob/master/ontology/ocimido.owl#OCIMIDO_00180 OCIMIDO LOOM
http://doe-generated-ontology.com/OntoPneumo#Cyclophosphamide ONTOPNEUMO LOOM
http://purl.bioontology.org/ontology/LNC/MTHU029970 LOINC LOOM
https://go.drugbank.com/drugs/DB00531 MDM LOOM
http://purl.obolibrary.org/obo/NCIT_C405 BERO LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146452 NDFRT LOOM
http://www.gamuts.net/entity#cyclophosphamide GAMUTS LOOM
http://purl.bioontology.org/ontology/ATC/L01AA01 ATC LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000039748 PDQ LOOM
http://purl.bioontology.org/ontology/VANDF/4018114 VANDF LOOM
http://purl.bioontology.org/ontology/RCD/h14.. RCD LOOM
http://purl.bioontology.org/ontology/MESH/D003520 MESH LOOM
http://purl.obolibrary.org/obo/OMIT_0004808 OMIT LOOM
http://localhost/plosthes.2017-1#6736 PLOSTHES LOOM
http://purl.obolibrary.org/obo/MESH_D003520 BERO LOOM
https://github.com/sap218/coid/blob/master/coid.owl#COID_00473 COID LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0010583 OCHV LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.705.672.500.243 RH-MESH LOOM
http://bmi.utah.edu/ontologies/hfontology/C0010583 HFO LOOM