Preferred Name |
Cyclophosphamide |
|
Synonyms |
2-[di(chloroethyl)amino]-1-oxa-3-aza-2-phosphacyclohexane 2-oxide monohydrate Syklofosfamid (-)-Cyclophosphamide 2H-1,3,2-Oxazaphosphorine, 2-[bis(2-chloroethyl)amino]tetrahydro-, 2-oxide, monohydrate Ciclofosfamida N,N-bis(beta-chloroethyl)-N',O-propylenephosphoric acid ester diamide monohydrate Cyclophosphamide Monohydrate 2-[bis(b-chloroethyl)amino]-1-oxa-3-aza-2-phosphacyclohexane-2-oxide monohydrate CYCLOPHOSPHAMIDE Cyclophosphamide cyclophosphamide Cyclophosphan Cyclophospham 1-bis(2-chloroethyl)-amino-1-oxo-2-aza-5-oxaphosphoridin monohydrate Cytophosphan Cytophosphane N,N-bis(2-chloroethyl)-N',O-propylenephosphoric acid ester diamide monohydrate CP monohydrate Cyclophosphamidum Cycloblastin Cycloblastine Ciclofosfamide N,N-bis(2-chloroethyl)-N'-(3-hydroxypropyl)phosphorodiamidic acid intramolecular ester monohydrate bis(2-chloroethyl)phosphamide cyclic propanolamide ester monohydrate N,N-bis(b-chloroethyl)-N',O-trimethylenephosphoric acid ester diamide monohydrate Cyclophosphanum N,N-bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide monohydrate Cyclophosphamid monohydrate N,N-bis(beta-chloroethyl)-N',O-trimethylenephosphoric acid ester diamide monohydrate 2-[bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide monohydrate Bis(2-chloroethyl)phosphoramide cyclic propanolamide ester monohydrate Cyclophosphane Asta B 518 B-518 CTX CYCLO-cell Carloxan Cicloxal Clafen Claphene Cyclostin Cyclostine Cytoxan Fosfaseron Genoxal Genuxal Ledoxina Mitoxan Neosar Revimmune WR- 138719 WR-138719 |
|
Definitions |
A synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities. In the liver, cyclophosphamide is converted to the active metabolites aldophosphamide and phosphoramide mustard, which bind to DNA, thereby inhibiting DNA replication and initiating cell death. |
|
ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C405 |
|
Accepted_Therapeutic_Use_For |
Breast cancer; Leukemias; Lupus nephritis; Lymphoma; Multiple myeloma; Neuroblastoma; Nephrotic syndrome; Ovarian cancer; Retinoblastoma; Acute Lymphoblastic Leukemia; Acute Myeloid Leukemia; Chronic Lymphocytic Leukemia; Chronic Myelogenous Leukemia |
|
ALT_DEFINITION |
A drug that is used to treat many types of cancer and is being studied in the treatment of other types of cancer. It is also used to treat some types of kidney disease in children. Cyclophosphamide attaches to DNA in cells and may kill cancer cells. It is a type of alkylating agent. |
|
CAS_Registry |
6055-19-2 |
|
CHEBI_ID |
CHEBI:4026 |
|
Chemical_Formula |
C7H15Cl2N2O2P.H2O |
|
code |
C405 |
|
Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173234 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C186328 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C186327 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C174019 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177383 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177406 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C186341 |
|
Contributing_Source |
CTRP FDA GDC HemOnc PCDC |
|
DEFINITION |
A synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities. In the liver, cyclophosphamide is converted to the active metabolites aldophosphamide and phosphoramide mustard, which bind to DNA, thereby inhibiting DNA replication and initiating cell death. |
|
Display_Name |
Cyclophosphamide |
|
FDA_UNII_Code |
8N3DW7272P |
|
FULL_SYN |
2-[di(chloroethyl)amino]-1-oxa-3-aza-2-phosphacyclohexane 2-oxide monohydrate Syklofosfamid (-)-Cyclophosphamide 2H-1,3,2-Oxazaphosphorine, 2-[bis(2-chloroethyl)amino]tetrahydro-, 2-oxide, monohydrate Ciclofosfamida N,N-bis(beta-chloroethyl)-N',O-propylenephosphoric acid ester diamide monohydrate Cyclophosphamide Monohydrate 2-[bis(b-chloroethyl)amino]-1-oxa-3-aza-2-phosphacyclohexane-2-oxide monohydrate CYCLOPHOSPHAMIDE Cyclophosphamide cyclophosphamide Cyclophosphan Cyclophospham 1-bis(2-chloroethyl)-amino-1-oxo-2-aza-5-oxaphosphoridin monohydrate Cytophosphan Cytophosphane N,N-bis(2-chloroethyl)-N',O-propylenephosphoric acid ester diamide monohydrate CP monohydrate Cyclophosphamidum Cycloblastin Cycloblastine Ciclofosfamide N,N-bis(2-chloroethyl)-N'-(3-hydroxypropyl)phosphorodiamidic acid intramolecular ester monohydrate bis(2-chloroethyl)phosphamide cyclic propanolamide ester monohydrate N,N-bis(b-chloroethyl)-N',O-trimethylenephosphoric acid ester diamide monohydrate Cyclophosphanum N,N-bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide monohydrate Cyclophosphamid monohydrate N,N-bis(beta-chloroethyl)-N',O-trimethylenephosphoric acid ester diamide monohydrate 2-[bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide monohydrate Bis(2-chloroethyl)phosphoramide cyclic propanolamide ester monohydrate Cyclophosphane Asta B 518 B-518 CTX CYCLO-cell Carloxan Cicloxal Clafen Claphene Cyclostin Cyclostine Cytoxan Fosfaseron Genoxal Genuxal Ledoxina Mitoxan Neosar Revimmune WR- 138719 WR-138719 |
|
Is_PCDC_AML_Authorized_Value_For_Variable | ||
Is_PCDC_GCT_Authorized_Value_For_Variable | ||
Is_Value_For_GDC_Property | ||
label |
Cyclophosphamide |
|
Legacy Concept Name |
Cyclophosphamide |
|
Maps_To |
Cyclophosphamide |
|
NCI_Drug_Dictionary_ID |
39748 |
|
NSC Number |
26271 |
|
PDQ_Closed_Trial_Search_ID |
39748 |
|
PDQ_Open_Trial_Search_ID |
39748 |
|
Preferred_Name |
Cyclophosphamide |
|
prefixIRI |
Thesaurus:C405 |
|
Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
UMLS_CUI |
C0010583 |
|
subClassOf |