loading...| Preferred Name |
Curcumin |
|
| Synonyms |
Diferuloylmethane Turmeric Yellow C.I. Natural Yellow 3 (E,E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione C.I. 75300 CURCUMIN Curcumin curcumin |
|
| Definitions |
A phytopolylphenol pigment isolated from the plant Curcuma longa, commonly known as turmeric, with a variety of pharmacologic properties. Curcumin blocks the formation of reactive-oxygen species, possesses anti-inflammatory properties as a result of inhibition of cyclooxygenases (COX) and other enzymes involved in inflammation; and disrupts cell signal transduction by various mechanisms including inhibition of protein kinase C. These effects may play a role in the agent's observed antineoplastic properties, which include inhibition of tumor cell proliferation and suppression of chemically induced carcinogenesis and tumor growth in animal models of cancer. (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C401 |
|
| ALT_DEFINITION |
A yellow pigment of the spice turmeric that is being studied in cancer prevention. |
|
| CAS_Registry |
458-37-7 |
|
| CHEBI_ID |
CHEBI:3962 |
|
| Chemical_Formula |
C21H20O6 |
|
| code |
C401 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
|
| Contributing_Source |
CTRP FDA GDC |
|
| DEFINITION |
A phytopolylphenol pigment isolated from the plant Curcuma longa, commonly known as turmeric, with a variety of pharmacologic properties. Curcumin blocks the formation of reactive-oxygen species, possesses anti-inflammatory properties as a result of inhibition of cyclooxygenases (COX) and other enzymes involved in inflammation; and disrupts cell signal transduction by various mechanisms including inhibition of protein kinase C. These effects may play a role in the agent's observed antineoplastic properties, which include inhibition of tumor cell proliferation and suppression of chemically induced carcinogenesis and tumor growth in animal models of cancer. (NCI04) |
|
| Display_Name |
Curcumin |
|
| FDA_UNII_Code |
IT942ZTH98 |
|
| FULL_SYN |
Diferuloylmethane Turmeric Yellow C.I. Natural Yellow 3 (E,E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione C.I. 75300 CURCUMIN Curcumin curcumin |
|
| Has_Target |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17984 |
|
| Is_Value_For_GDC_Property | ||
| label |
Curcumin |
|
| Legacy Concept Name |
Curcumin |
|
| Maps_To |
Curcumin |
|
| NCI_Drug_Dictionary_ID |
43115 |
|
| NSC Number |
32982 |
|
| PDQ_Closed_Trial_Search_ID |
43115 |
|
| PDQ_Open_Trial_Search_ID |
43115 |
|
| Preferred_Name |
Curcumin |
|
| prefixIRI |
Thesaurus:C401 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0010467 |
|
| subClassOf |