National Cancer Institute Thesaurus

Last uploaded: October 28, 2019
Preferred Name

Alteplase

Synonyms

Plasminogen Activator (Human Tissue-Type Protein Moiety)

Alteplase

Activase

Recombinant Tissue Plasminogen Activator

r-tPA

recombinant tissue plasminogen activator

ALTEPLASE

rt-PA

Definitions

A recombinant therapeutic agent which is chemically identical to or similar to endogenous tissue plasminogen activator (tPA). tPA is a serine protease which converts plasminogen to plasmin, a fibrinolytic enzyme. Upon administration, alteplase increases plasmin enzymatic activity, resulting in hyperfibrinolysis and potential dissolution of a thrombus or embolism.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C39607

ALT_DEFINITION

A form of tissue plasminogen activator that is made in the laboratory. It helps dissolve blood clots and is used to treat heart attacks, strokes, and clots in the lungs. It is also being studied in the treatment of cancer. It is a type of systemic thrombolytic agent.

CAS_Registry

105857-23-6

code

C39607

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A recombinant therapeutic agent which is chemically identical to or similar to endogenous tissue plasminogen activator (tPA). tPA is a serine protease which converts plasminogen to plasmin, a fibrinolytic enzyme. Upon administration, alteplase increases plasmin enzymatic activity, resulting in hyperfibrinolysis and potential dissolution of a thrombus or embolism.

FDA_UNII_Code

1RXS4UE564

FULL_SYN

Plasminogen Activator (Human Tissue-Type Protein Moiety)

Alteplase

Activase

Recombinant Tissue Plasminogen Activator

r-tPA

recombinant tissue plasminogen activator

ALTEPLASE

rt-PA

Is_Related_To_Endogenous_Product

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16995

label

Alteplase

Legacy_Concept_Name

Recombinant_Tissue_Plasminogen_Activator

PDQ_Closed_Trial_Search_ID

42033

PDQ_Open_Trial_Search_ID

42033

Preferred_Name

Alteplase

prefixIRI

ncit:C39607

Semantic_Type

Pharmacologic Substance

Amino Acid, Peptide, or Protein

UMLS_CUI

C0032143

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29750

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