loading...| Preferred Name |
Axitinib |
|
| Synonyms |
N-methyl-2-((3-((1E)-2-(pyridin-2-yl)ethenyl)-1H-indazol-6-yl)sulfanyl)benzamide AG-013736 AG013736 AXITINIB Axitinib Inlyta axitinib |
|
| Definitions |
An orally bioavailable tyrosine kinase inhibitor. Axitinib inhibits the proangiogenic cytokines vascular endothelial growth factor (VEGF) and platelet-derived growth factor receptor (PDGF), thereby exerting an anti-angiogenic effect. |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C38718 |
|
| ALT_DEFINITION |
A substance that is being studied in the treatment of cancer. It belongs to the families of drugs called angiogenesis inhibitors and protein tyrosine kinase inhibitors. |
|
| CAS_Registry |
319460-85-0 |
|
| Chemical_Formula |
C22H18N4OS |
|
| code |
C38718 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
|
| Contributing_Source |
CTRP FDA GDC HemOnc |
|
| DEFINITION |
An orally bioavailable tyrosine kinase inhibitor. Axitinib inhibits the proangiogenic cytokines vascular endothelial growth factor (VEGF) and platelet-derived growth factor receptor (PDGF), thereby exerting an anti-angiogenic effect. |
|
| Display_Name |
Axitinib |
|
| FDA_UNII_Code |
C9LVQ0YUXG |
|
| FULL_SYN |
N-methyl-2-((3-((1E)-2-(pyridin-2-yl)ethenyl)-1H-indazol-6-yl)sulfanyl)benzamide AG-013736 AG013736 AXITINIB Axitinib Inlyta axitinib |
|
| Has_Target | ||
| Is_Value_For_GDC_Property | ||
| label |
Axitinib |
|
| Legacy Concept Name |
AG-013736 |
|
| Maps_To |
Axitinib |
|
| NCI_Drug_Dictionary_ID |
352181 |
|
| PDQ_Closed_Trial_Search_ID |
352181 |
|
| PDQ_Open_Trial_Search_ID |
352181 |
|
| Preferred_Name |
Axitinib |
|
| prefixIRI |
Thesaurus:C38718 |
|
| Semantic_Type |
Pharmacologic Substance |
|
| UMLS_CUI |
C1700874 |
|
| subClassOf |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C159199 |