loading...| Preferred Name |
Anakinra |
|
| Synonyms |
ANAKINRA Anakinra Kinaret Kineret anakinra rIL-1ra rIL1RN |
|
| Definitions |
A recombinant human nonglycosylated interleukin-1 (IL-1) receptor antagonist with potential antineoplastic activity. Anakinra binds to the IL-1 receptor, thereby blocking the binding of the IL-1 to and activation of its receptor. Blockade of IL-1 activity may inhibit the cascade of downstream pro-angiogenic factors such as vascular endothelial cell growth factor, tumor necrosis factor-alpha, and IL-6, resulting in inhibition of tumor angiogenesis. (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C38717 |
|
| Accepted_Therapeutic_Use_For |
Rheumatoid arthritis |
|
| ALT_DEFINITION |
A substance that is used to treat rheumatoid arthritis, and is being studied in the treatment of cancer. Anakinra blocks the action of interleukin 1 (IL-1). It is a type of interleukin receptor antagonist. |
|
| CAS_Registry |
143090-92-0 |
|
| code |
C38717 |
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173383 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
|
| Contributing_Source |
CTRP FDA GDC HemOnc |
|
| DEFINITION |
A recombinant human nonglycosylated interleukin-1 (IL-1) receptor antagonist with potential antineoplastic activity. Anakinra binds to the IL-1 receptor, thereby blocking the binding of the IL-1 to and activation of its receptor. Blockade of IL-1 activity may inhibit the cascade of downstream pro-angiogenic factors such as vascular endothelial cell growth factor, tumor necrosis factor-alpha, and IL-6, resulting in inhibition of tumor angiogenesis. (NCI04) |
|
| Display_Name |
Anakinra |
|
| FDA_UNII_Code |
9013DUQ28K |
|
| FULL_SYN |
ANAKINRA Anakinra Kinaret Kineret anakinra rIL-1ra rIL1RN |
|
| Has_Target | ||
| Is_Related_To_Endogenous_Product | ||
| Is_Value_For_GDC_Property | ||
| label |
Anakinra |
|
| Legacy Concept Name |
Anakinra |
|
| Maps_To |
Anakinra |
|
| NCI_Drug_Dictionary_ID |
43007 |
|
| PDQ_Closed_Trial_Search_ID |
43007 |
|
| PDQ_Open_Trial_Search_ID |
43007 |
|
| Preferred_Name |
Anakinra |
|
| prefixIRI |
Thesaurus:C38717 |
|
| Semantic_Type |
Pharmacologic Substance |
|
| UMLS_CUI |
C0245109 |
|
| subClassOf |