National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Lamotrigine

Synonyms

Lamotrigine

lamotrigine

LAMOTRIGINE

Lamictal

Definitions

A synthetic phenyltriazine with antiepileptic and analgesic properties. Lamotrigine enhances the action of gamma-aminobutyric acid, an inhibitory neurotransmitter, which may result in a reduction of pain-related transmission of signals along nerve fibers. This agent may also inhibit voltage-gated sodium channels, suppress glutamate release, and inhibit serotonin reuptake. (NCI04)

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C38703

Accepted_Therapeutic_Use_For

Epilepsy

ALT_DEFINITION

A drug that is used to help control some types of seizures. It is being studied in the prevention of peripheral neuropathy caused by some chemotherapy drugs. It belongs to the family of drugs called anticonvulsants.

CAS_Registry

84057-84-1

CHEBI_ID

CHEBI:6367

Chemical_Formula

C9H7Cl2N5

code

C38703

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A synthetic phenyltriazine with antiepileptic and analgesic properties. Lamotrigine enhances the action of gamma-aminobutyric acid, an inhibitory neurotransmitter, which may result in a reduction of pain-related transmission of signals along nerve fibers. This agent may also inhibit voltage-gated sodium channels, suppress glutamate release, and inhibit serotonin reuptake. (NCI04)

DesignNote

Clinical Trial--Chemotherapy-induced neuropathy

FDA_UNII_Code

U3H27498KS

FULL_SYN

Lamotrigine

lamotrigine

LAMOTRIGINE

Lamictal

label

Lamotrigine

Legacy Concept Name

Lamotrigine

NCI_Drug_Dictionary_ID

328241

PDQ_Closed_Trial_Search_ID

328241

PDQ_Open_Trial_Search_ID

328241

Preferred_Name

Lamotrigine

prefixIRI

Thesaurus:C38703

Semantic_Type

Organic Chemical

Pharmacologic Substance

UMLS_CUI

C0064636

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C264

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Delete Mapping To Ontology Source
http://purl.obolibrary.org/obo/CHEBI_6367 OBA LOOM
http://www.case.edu/EpilepsyOntology.owl#Lamotrigine EPSO LOOM
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClassf3e643e0_10a0_40bd_b179_094408e6d8d9 WWECA LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C047781 RH-MESH LOOM
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClassf39fbedb_ebe7_4f63_a429_ea14be7212fd WWECA LOOM
http://purl.bioontology.org/ontology/NDDF/003988 NDDF LOOM
http://purl.bioontology.org/ontology/LNC/MTHU060528 LOINC LOOM
http://purl.obolibrary.org/obo/NCIT_C38703 BERO LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0064636 OCHV LOOM
http://www.phoc.org.cn/pmo/class/PMO_00026568 PMAPP-PMO LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000328241 PDQ LOOM
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http://purl.bioontology.org/ontology/LNC/LP17251-7 LOINC LOOM
http://purl.bioontology.org/ontology/RCD/dnf.. RCD LOOM
http://purl.bioontology.org/ontology/RXNORM/28439 RXNORM LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#14273 OCHV LOOM
http://purl.jp/bio/4/id/200906050879505783 IOBC LOOM
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http://www.semanticweb.org/ftuha/ontologies/2021/5/FRMO-01untitled-ontology-175/Lamotrigine FRMO LOOM
http://purl.bioontology.org/ontology/ATC/N03AX09 ATC LOOM
http://purl.obolibrary.org/obo/CHEBI_6367 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_6367 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_6367 DINTO LOOM
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http://purl.obolibrary.org/obo/CHEBI_6367 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_6367 OBA LOOM
http://purl.obolibrary.org/obo/CHEBI_6367 CHEBI LOOM
https://bioportal.bioontology.org/ontologies/STMSO#Lamotrigine STMSO LOOM
http://purl.bioontology.org/ontology/VANDF/4020896 VANDF LOOM
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http://purl.bioontology.org/ontology/SNOMEDCT/387562000 SNOMEDCT LOOM
http://stirdf.jst.go.jp/id/200907015386390689 IOBC LOOM
http://purl.bioontology.org/ontology/SNMI/C-61170 SNMI LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148390 NDFRT LOOM
http://scai.fraunhofer.de/MSOntology#Lamotrigine MSO LOOM
http://purl.bioontology.org/ontology/MESH/D000077213 MESH LOOM
http://www.co-ode.org/ontologies/galen#Lamotrigine GALEN LOOM
http://purl.bioontology.org/ontology/CPT/80175 CPT LOOM
https://go.drugbank.com/drugs/DB00555 MDM LOOM
http://www.drugbank.ca/drugs/DB00555 FTC LOOM