National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Cholesterol

Synonyms

cholesterol

(-)-Cholesterol

5-cholesten-3B-ol

(3beta)-Cholest-5-en-3-ol

CHOLESTEROL

Cholesterol

Definitions

An animal sterol found in the body tissues (and blood plasma) of vertebrates. It can be found in large concentrations within the liver, spinal cord, and brain. Cholesterol is an important component of the membranes of cells, providing stability. It is the major precursor for the synthesis of vitamin D, of the various steroid hormones, including cortisol, cortisone, and aldosterone in the adrenal glands, and of the sex hormones progesterone, estrogen, and testosterone. Cholesterol also has an important role for the brain synapses as well as in the immune system. In conditions featuring elevated low density lipoproteins (LDL), cholesterol often forms plaque deposits in the walls of arteries, a condition known as atherosclerosis, which is a major contributor to coronary heart disease and other forms of cardiovascular disease.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C369

ALT_DEFINITION

Lipid composed of 27 carbon atoms which form three fused cycloheane (6-carbon) rings, a cyclopentane (5-carbon ring) and a side chain of 8 carbon atoms. (Ensminger et al).

A waxy, fat-like substance made in the liver, and found in the blood and in all cells of the body. Cholesterol is important for good health and is needed for making cell walls, tissues, hormones, vitamin D, and bile acid. Cholesterol also comes from eating foods taken from animals such as egg yolks, meat, and whole-milk dairy products. Too much cholesterol in the blood may build up in blood vessel walls, block blood flow to tissues and organs, and increase the risk of developing heart disease and stroke.

CAS_Registry

57-88-5

CHEBI_ID

CHEBI:16113

Chemical_Formula

C27H46O

code

C369

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142799

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

CRCH

CTRP

FDA

DEFINITION

An animal sterol found in the body tissues (and blood plasma) of vertebrates. It can be found in large concentrations within the liver, spinal cord, and brain. Cholesterol is an important component of the membranes of cells, providing stability. It is the major precursor for the synthesis of vitamin D, of the various steroid hormones, including cortisol, cortisone, and aldosterone in the adrenal glands, and of the sex hormones progesterone, estrogen, and testosterone. Cholesterol also has an important role for the brain synapses as well as in the immune system. In conditions featuring elevated low density lipoproteins (LDL), cholesterol often forms plaque deposits in the walls of arteries, a condition known as atherosclerosis, which is a major contributor to coronary heart disease and other forms of cardiovascular disease.

Display_Name

Cholesterol

FDA_UNII_Code

97C5T2UQ7J

FULL_SYN

cholesterol

(-)-Cholesterol

5-cholesten-3B-ol

(3beta)-Cholest-5-en-3-ol

CHOLESTEROL

Cholesterol

INFOODS

CHOLE

label

Cholesterol

Legacy Concept Name

Cholesterol

NSC Number

8798

Preferred_Name

Cholesterol

prefixIRI

Thesaurus:C369

Semantic_Type

Organic Chemical

UMLS_CUI

C0008377

Unit

mg

US_Recommended_Intake

Y

USDA_ID

601

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C68342

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Delete Mapping To Ontology Source
http://purl.obolibrary.org/obo/CHEBI_16113 EFO LOOM
http://www.phoc.org.cn/pmo/class/PMO_00018598 PMAPP-PMO LOOM
http://purl.bioontology.org/ontology//30870 METABUS LOOM
https://go.drugbank.com/drugs/DB04540 MDM LOOM
http://stirdf.jst.go.jp/id/200907040526382996 IOBC LOOM
http://doe-generated-ontology.com/OntoAD#C0008377 ONTOAD LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D10.851.208 RH-MESH LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#2883 OCHV LOOM
http://purl.obolibrary.org/obo/LION_0000541 LION LOOM
http://www.semanticweb.org/ontologies/2018/1/ProstateCancer.owl#Cholesterol PCAO LOOM
http://purl.bioontology.org/ontology/SNMI/F-63980 SNMI LOOM
http://purl.bioontology.org/ontology/RCD/X80Iz RCD LOOM
http://purl.obolibrary.org/obo/MESH_D002784 BERO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D10.570.938.208 RH-MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D04.808.247.808.197 RH-MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D04.808.247.222.284 RH-MESH LOOM
http://purl.obolibrary.org/obo/dinto_DB04540 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_16113 FOODON LOOM
http://purl.obolibrary.org/obo/CHEBI_16113 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_16113 OBI LOOM
http://purl.obolibrary.org/obo/CHEBI_16113 OCMR LOOM
http://purl.obolibrary.org/obo/CHEBI_16113 HOIP LOOM
http://purl.obolibrary.org/obo/CHEBI_16113 CDNO LOOM
http://purl.obolibrary.org/obo/CHEBI_16113 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_16113 HUPSON LOOM
http://purl.obolibrary.org/obo/CHEBI_16113 HHEAR LOOM
http://purl.obolibrary.org/obo/CHEBI_16113 TXPO LOOM
http://purl.obolibrary.org/obo/CHEBI_16113 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_16113 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_16113 OBA LOOM
http://purl.obolibrary.org/obo/CHEBI_16113 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_16113 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_16113 UPHENO LOOM
http://purl.obolibrary.org/obo/CHEBI_16113 ONSTR LOOM
http://purl.obolibrary.org/obo/CHEBI_16113 HINO LOOM
http://purl.obolibrary.org/obo/CHEBI_16113 MAXO LOOM
http://purl.obolibrary.org/obo/CHEBI_16113 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_16113 ZP LOOM
http://purl.jp/bio/4/id/200906081386040806 IOBC LOOM
http://purl.jp/bio/10/gmo/GMO_001821 GMO LOOM
http://scai.fraunhofer.de/CSEO#CSEO_00000455 CSEO LOOM
http://purl.obolibrary.org/obo/UPa_UPC00187 UPA LOOM
http://purl.bioontology.org/ontology/RXNORM/2438 RXNORM LOOM
http://www.co-ode.org/ontologies/galen#Cholesterol GALEN LOOM
http://purl.bioontology.org/ontology/MEDLINEPLUS/C0008377 MEDLINEPLUS LOOM
http://www.case.edu/ProvCaRe/provcare#Cholesterol NEUROBRG LOOM
http://purl.bioontology.org/ontology/LNC/LP15493-7 LOINC LOOM
http://scai.fraunhofer.de/MSOntology#Cholesterol MSO LOOM
http://purl.bioontology.org/ontology/LNC/LP100019-1 LOINC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D002784 RH-MESH LOOM
http://www.semanticweb.org/emif/ontologies/2015/AD/RCk2pI0Wx0KWtHVGYxbWFi0 EMIF-AD LOOM
http://purl.obolibrary.org/obo/NCIT_C369 BERO LOOM
http://purl.bioontology.org/ontology/MESH/D002784 MESH LOOM
http://purl.bioontology.org/ontology/NDDF/002556 NDDF LOOM
http://purl.org/metabus/30870 TESTING_BOSCO LOOM
http://purl.org/metabus/30870 METABUS LOOM
http://www.semanticweb.org/ADMO#cholesterol ADMO LOOM
http://scai.fraunhofer.de/AlzheimerOntology#cholesterol ADO LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146961 NDFRT LOOM
http://purl.bioontology.org/ontology/CSP/0658-4141 CRISP LOOM
http://purl.obolibrary.org/obo/OMIT_0004104 OMIT LOOM
http://purl.bioontology.org/ontology/MEDDRA/10008650 MEDDRA LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0008377 OCHV LOOM
http://purl.bioontology.org/ontology/VANDF/4018648 VANDF LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/84698008 SNOMEDCT LOOM
http://ontology.apa.org/apaonto/termsonlyOUT%20(5).owl#Cholesterol APAONTO LOOM
http://localhost/plosthes.2017-1#8788 PLOSTHES LOOM
http://purl.bioontology.org/ontology/LNC/MTHU003147 LOINC LOOM
http://www.pepathway.org/peo/1.2#cholesterol PE-O LOOM
http://www.projecthalo.com/aura#Cholesterol AURA LOOM