National Cancer Institute Thesaurus

Last uploaded: July 29, 2019
Preferred Name

Chlorhexidine

Synonyms

Chlorhexidine

CHLORHEXIDINE

Definitions

A biguanide compound used as an antiseptic agent with topical antibacterial activity. Chlorhexidine is positively charged and reacts with the negatively charged microbial cell surface, thereby destroying the integrity of the cell membrane. Subsequently, chlorhexidine penetrates into the cell and causes leakage of intracellular components leading to cell death. Since gram positive bacteria are more negatively charged, they are more sensitive to this agent.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C364

CAS_Registry

55-56-1

CHEBI_ID

CHEBI:3614

Chemical_Formula

C22H30Cl2N10

code

C364

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

Contributing_Source

CTRP

FDA

DEFINITION

A biguanide compound used as an antiseptic agent with topical antibacterial activity. Chlorhexidine is positively charged and reacts with the negatively charged microbial cell surface, thereby destroying the integrity of the cell membrane. Subsequently, chlorhexidine penetrates into the cell and causes leakage of intracellular components leading to cell death. Since gram positive bacteria are more negatively charged, they are more sensitive to this agent.

Display_Name

Chlorhexidine

FDA_UNII_Code

R4KO0DY52L

FULL_SYN

Chlorhexidine

CHLORHEXIDINE

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C65314

label

Chlorhexidine

Legacy_Concept_Name

Chlorhexidine

PDQ_Closed_Trial_Search_ID

41544

PDQ_Open_Trial_Search_ID

41544

Preferred_Name

Chlorhexidine

prefixIRI

ncit:C364

Semantic_Type

Organic Chemical

Antibiotic

UMLS_CUI

C0008196

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28394

Delete Subject Author Type Created
No notes to display
Create New Mapping

Delete Mapping To Ontology Source
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.078.370.141.100 RH-MESH LOOM
http://www.co-ode.org/ontologies/galen#Chlorhexidine GALEN LOOM
http://purl.bioontology.org/ontology/SNMI/C-90250 SNMI LOOM
http://purl.jp/bio/4/id/200906045186180011 IOBC LOOM
http://purl.jp/bio/4/id/200906045186180011 IOBC LOOM
http://purl.jp/bio/4/id/200906045186180011 IOBC LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147765 NDFRT LOOM
http://purl.bioontology.org/ontology/MESH/D002710 MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D002710 RH-MESH LOOM
http://data.bnf.fr/ark:/12148/cb12266566s FAST-TOPICAL LOOM
http://purl.bioontology.org/ontology/UATC/S01AX09 ATC LOOM
http://purl.bioontology.org/ontology/UATC/S03AA04 ATC LOOM
http://purl.bioontology.org/ontology/VANDF/4019673 VANDF LOOM
http://purl.obolibrary.org/obo/CHEBI_3614 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_3614 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_3614 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_3614 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_3614 CCONT LOOM
http://purl.obolibrary.org/obo/CHEBI_3614 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_3614 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_3614 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_3614 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_3614 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_3614 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_3614 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_3614 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_3614 NIFSTD LOOM
http://purl.obolibrary.org/obo/CHEBI_3614 EFO LOOM
http://purl.bioontology.org/ontology/UATC/S02AA09 ATC LOOM
http://purl.bioontology.org/ontology/RCD/x001v RCD LOOM
http://purl.bioontology.org/ontology/UATC/D09AA12 ATC LOOM
http://purl.bioontology.org/ontology/NDDF/003674 NDDF LOOM
http://purl.bioontology.org/ontology/LNC/LP128648-5 LOINC LOOM
http://purl.bioontology.org/ontology/RXNORM/2358 RXNORM LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000041544 PDQ LOOM
http://purl.bioontology.org/ontology/UATC/R02AA05 ATC LOOM
http://purl.bioontology.org/ontology/UATC/B05CA02 ATC LOOM
http://stirdf.jst.go.jp/id/200907087158651090 IOBC LOOM
http://stirdf.jst.go.jp/id/200907087158651090 IOBC LOOM
http://stirdf.jst.go.jp/id/200907087158651090 IOBC LOOM
http://purl.bioontology.org/ontology/UATC/D08AC02 ATC LOOM
http://purl.bioontology.org/ontology/UATC/A01AB03 ATC LOOM
http://purl.bioontology.org/ontology/CSP/1357-0106 CRISP LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/373568007 SNOMEDCT LOOM