loading...| Preferred Name |
Chlorambucil |
|
| Synonyms |
Chlorobutin N,N-di-2-chloroethyl-gamma-p-aminophenylbutyric acid CHLORAMBUCIL Chlorbutine Chloraminophen Chloraminophene gamma-[p-di(2-chloroethyl)aminophenyl]butyric acid butyric acid, 4-(p-bis(2-chloroethyl)aminophenyl) chlorambucil Butyric acid, 4-(p-[bis(2-chloroethyl)amino]phenyl)- aminochlorambucil chlorbutinum Chlorobutine chloroambucil Aminochlorambucil p-N, N-di-(beta-chloroethyl)aminophenyl butyric acid Benzenebutanoic acid, 4-[bis(2-chloroethyl)amino]- (9CI) .gamma.-[p-bis(2-chloroethyl)aminophenyl]butyric acid 4-[p-[Bis(2-chloroethyl)amino]phenyl]butyric acid gamma-(p-bis(2-chloroethyl)aminophenyl)butyric acid Chlorambucilum N,N-Di-2-chloroethyl-.gamma.-p-aminophenylbutyric acid Chlorambucil .gamma.-[p-Di(2-chloroethyl)aminophenyl]butyric acid Butyric acid, 4-(p-bis(2-chloroethyl)aminophenyl)- p-N, N-Di-(.beta.-chloroethyl)aminophenyl butyric acid 4-[bis(2-chloroethyl)amino]benzenebutanoic acid p-(N, N-di-2-chloroethyl)aminophenyl butyric acid benzenebutanoic acid, 4-[bis(2-chloroethyl)amino]- (9CI) phenylbutyric acid nitrogen mustard Alti-chlorambucil Phenylbutyric acid nitrogen mustard Chloroambucil p-(N, N-Di-2-chloroethyl)aminophenyl butyric acid 4-[p-[bis(2-chloroethyl)amino]phenyl]butyric acid Ambochlorin .gamma.-(p-bis(2-chloroethyl)aminophenyl)butyric acid 4-[Bis(2-chloroethyl)amino]benzenebutanoic acid Lympholysin Amboclorin CB 1348 CB-1348 CHL Chlorbutin Ecloril Elcoril Leukeran Leukersan Leukoran Linfolizin Linfolysin WR-139013 |
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| Definitions |
An orally-active antineoplastic aromatic nitrogen mustard. Chlorambucil alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. (NCI04) |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C362 |
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| Accepted_Therapeutic_Use_For |
chronic lymphocytic leukemia, Hodgkin lymphoma, and certain types of non-Hodgkin lymphoma. |
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| ALT_DEFINITION |
A drug used to treat several types of leukemias and lymphomas. It blocks cell growth by damaging the cell's DNA and may kill cancer cells. It is a type of alkylating agent. |
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| CAS_Registry |
305-03-3 |
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| CHEBI_ID |
CHEBI:28830 |
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| Chemical_Formula |
C14H19Cl2NO2 |
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| code |
C362 |
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
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| Contributing_Source |
CTRP FDA GDC HemOnc |
|
| DEFINITION |
An orally-active antineoplastic aromatic nitrogen mustard. Chlorambucil alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. (NCI04) |
|
| Display_Name |
Chlorambucil |
|
| FDA_UNII_Code |
18D0SL7309 |
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| FULL_SYN |
Chlorobutin N,N-di-2-chloroethyl-gamma-p-aminophenylbutyric acid CHLORAMBUCIL Chlorbutine Chloraminophen Chloraminophene gamma-[p-di(2-chloroethyl)aminophenyl]butyric acid butyric acid, 4-(p-bis(2-chloroethyl)aminophenyl) chlorambucil Butyric acid, 4-(p-[bis(2-chloroethyl)amino]phenyl)- aminochlorambucil chlorbutinum Chlorobutine chloroambucil Aminochlorambucil p-N, N-di-(beta-chloroethyl)aminophenyl butyric acid Benzenebutanoic acid, 4-[bis(2-chloroethyl)amino]- (9CI) .gamma.-[p-bis(2-chloroethyl)aminophenyl]butyric acid 4-[p-[Bis(2-chloroethyl)amino]phenyl]butyric acid gamma-(p-bis(2-chloroethyl)aminophenyl)butyric acid Chlorambucilum N,N-Di-2-chloroethyl-.gamma.-p-aminophenylbutyric acid Chlorambucil .gamma.-[p-Di(2-chloroethyl)aminophenyl]butyric acid Butyric acid, 4-(p-bis(2-chloroethyl)aminophenyl)- p-N, N-Di-(.beta.-chloroethyl)aminophenyl butyric acid 4-[bis(2-chloroethyl)amino]benzenebutanoic acid p-(N, N-di-2-chloroethyl)aminophenyl butyric acid benzenebutanoic acid, 4-[bis(2-chloroethyl)amino]- (9CI) phenylbutyric acid nitrogen mustard Alti-chlorambucil Phenylbutyric acid nitrogen mustard Chloroambucil p-(N, N-Di-2-chloroethyl)aminophenyl butyric acid 4-[p-[bis(2-chloroethyl)amino]phenyl]butyric acid Ambochlorin .gamma.-(p-bis(2-chloroethyl)aminophenyl)butyric acid 4-[Bis(2-chloroethyl)amino]benzenebutanoic acid Lympholysin Amboclorin CB 1348 CB-1348 CHL Chlorbutin Ecloril Elcoril Leukeran Leukersan Leukoran Linfolizin Linfolysin WR-139013 |
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| Is_Value_For_GDC_Property | ||
| label |
Chlorambucil |
|
| Legacy Concept Name |
Chlorambucil |
|
| Maps_To |
Chlorambucil |
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| NCI_Drug_Dictionary_ID |
43113 |
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| NSC Number |
3088 |
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| PDQ_Closed_Trial_Search_ID |
43113 |
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| PDQ_Open_Trial_Search_ID |
43113 |
|
| Preferred_Name |
Chlorambucil |
|
| prefixIRI |
Thesaurus:C362 |
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| Semantic_Type |
Organic Chemical Pharmacologic Substance |
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| UMLS_CUI |
C0008163 |
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| subClassOf |