National Cancer Institute Thesaurus

Last uploaded: June 25, 2019
Preferred Name

Cephalosporin Antibiotic

Synonyms

cephalosporin

Cephalosporins

Cephalosporin Antibiotic

Definitions

A synthetic or semi-synthetic beta-lactam antibiotic derived from Acremonium (Cephalosporium) fungi with bactericidal activity. Cephalosporin antibiotics bind to and inactivate penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening of the bacterial cell wall, eventually causing cell lysis.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C357

ALT_DEFINITION

A drug used to treat bacterial infections. It belongs to the family of drugs called antibiotics.

CHEBI_ID

CHEBI:23066

code

C357

DEFINITION

A synthetic or semi-synthetic beta-lactam antibiotic derived from Acremonium (Cephalosporium) fungi with bactericidal activity. Cephalosporin antibiotics bind to and inactivate penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening of the bacterial cell wall, eventually causing cell lysis.

FULL_SYN

cephalosporin

Cephalosporins

Cephalosporin Antibiotic

label

Cephalosporin Antibiotic

Legacy_Concept_Name

Cephalosporin_Antibiotic

Preferred_Name

Cephalosporin Antibiotic

prefixIRI

ncit:C357

Semantic_Type

Chemical Viewed Functionally

UMLS_CUI

C3536856

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C260

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