National Cancer Institute Thesaurus

Last uploaded: May 28, 2019
Preferred Name

Cefotaxime

Synonyms

Cefotaxime

CEFOTAXIME

Definitions

A third generation semisynthetic cephalosporin antibiotic with bactericidal activity. Cefotaxime inhibits mucopeptide synthesis by binding to and inactivating penicillin binding proteins thereby interfering with the final transpeptidation step required for cross-linking of peptidoglycan units which are a component of bacterial cell walls. This results in a reduction of cell wall stability and causes cell lysis.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C354

CAS_Registry

63527-52-6

CHEBI_ID

CHEBI:204928

Chemical_Formula

C16H17N5O7S2

code

C354

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A third generation semisynthetic cephalosporin antibiotic with bactericidal activity. Cefotaxime inhibits mucopeptide synthesis by binding to and inactivating penicillin binding proteins thereby interfering with the final transpeptidation step required for cross-linking of peptidoglycan units which are a component of bacterial cell walls. This results in a reduction of cell wall stability and causes cell lysis.

FDA_UNII_Code

N2GI8B1GK7

FULL_SYN

Cefotaxime

CEFOTAXIME

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2328

label

Cefotaxime

Legacy_Concept_Name

Cefotaxime

PDQ_Closed_Trial_Search_ID

39177

PDQ_Open_Trial_Search_ID

39177

Preferred_Name

Cefotaxime

prefixIRI

ncit:C354

Semantic_Type

Organic Chemical

Antibiotic

UMLS_CUI

C0007554

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C357

Delete Subject Author Type Created
No notes to display
Create New Mapping

Delete Mapping To Ontology Source
http://purl.bioontology.org/ontology/UATC/J01DD01 ATC LOOM
http://purl.bioontology.org/ontology/LNC/MTHU002074 LOINC LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/372704003 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/LNC/LP14831-9 LOINC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.886.665.074.190.190 RH-MESH LOOM
http://stirdf.jst.go.jp/id/200907009723540531 IOBC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.065.589.099.249.190.190 RH-MESH LOOM
http://purl.bioontology.org/ontology/NDDF/004845 NDDF LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000039177 PDQ LOOM
http://purl.jp/bio/4/id/200906042877350186 IOBC LOOM
http://purl.bioontology.org/ontology/MESH/D002439 MESH LOOM
http://www.co-ode.org/ontologies/galen#Cefotaxime GALEN LOOM
http://purl.bioontology.org/ontology/SNMI/C-53530 SNMI LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147755 NDFRT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D04.075.080.875.099.221.249.190.190 RH-MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D002439 RH-MESH LOOM
http://purl.bioontology.org/ontology/RXNORM/2186 RXNORM LOOM
http://purl.obolibrary.org/obo/CHEBI_204928 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_204928 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_204928 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_204928 GENEPIO LOOM
http://purl.obolibrary.org/obo/CHEBI_204928 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_204928 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_204928 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_204928 NIFSTD LOOM
http://purl.bioontology.org/ontology/VANDF/4019663 VANDF LOOM
http://id.loc.gov/authorities/subjects/sh90001869 FAST-TOPICAL LOOM