loading...| Preferred Name |
Calcitriol |
|
| Synonyms |
(1alpha,3beta,5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol 1,25(OH)2-D3 1,25-Dihydroxycholecalciferol 1,25-Dihydroxycholecaliferol 1,25-DHCC CALCITRIOL Calcijex Calcitriol Rocaltrol calcitriol |
|
| Definitions |
A synthetic physiologically-active analog of vitamin D, specifically the vitamin D3 form. Calcitriol regulates calcium in vivo by promoting absorption in the intestine, reabsorption in the kidneys, and, along with parathyroid hormone, regulation of bone growth. A calcitriol receptor-binding protein appears to exist in the mucosa of human intestine. Calcitriol also induces cell cycle arrest at G0/G1 phase of the cell cycle, cell differentiation, and apoptosis, resulting in inhibition of proliferation of some tumor cell types. This agent may be chemopreventive for colon and prostate cancers. (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C330 |
|
| Accepted_Therapeutic_Use_For |
Hyperparathyroidism; Hypocalcemia |
|
| ALT_DEFINITION |
The active form of vitamin D. Calcitriol is formed in the kidneys or made in the laboratory. It is used as a drug to increase calcium levels in the body in order to treat skeletal and tissue-related calcium deficiencies caused by kidney or thyroid disorders. |
|
| CAS_Registry |
32222-06-3 |
|
| CHEBI_ID |
CHEBI:17823 |
|
| Chemical_Formula |
C27H44O3 |
|
| code |
C330 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142799 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
|
| Contributing_Source |
CTRP FDA GDC |
|
| DEFINITION |
A synthetic physiologically-active analog of vitamin D, specifically the vitamin D3 form. Calcitriol regulates calcium in vivo by promoting absorption in the intestine, reabsorption in the kidneys, and, along with parathyroid hormone, regulation of bone growth. A calcitriol receptor-binding protein appears to exist in the mucosa of human intestine. Calcitriol also induces cell cycle arrest at G0/G1 phase of the cell cycle, cell differentiation, and apoptosis, resulting in inhibition of proliferation of some tumor cell types. This agent may be chemopreventive for colon and prostate cancers. (NCI04) |
|
| Display_Name |
Calcitriol |
|
| FDA_UNII_Code |
FXC9231JVH |
|
| FULL_SYN |
(1alpha,3beta,5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol 1,25(OH)2-D3 1,25-Dihydroxycholecalciferol 1,25-Dihydroxycholecaliferol 1,25-DHCC CALCITRIOL Calcijex Calcitriol Rocaltrol calcitriol |
|
| Is_Value_For_GDC_Property | ||
| label |
Calcitriol |
|
| Legacy Concept Name |
Calcitriol |
|
| Maps_To |
Calcitriol |
|
| NCI_Drug_Dictionary_ID |
41919 |
|
| PDQ_Closed_Trial_Search_ID |
41919 |
|
| PDQ_Open_Trial_Search_ID |
41919 |
|
| Preferred_Name |
Calcitriol |
|
| prefixIRI |
Thesaurus:C330 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0006674 |
|
| subClassOf |