National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Busulfan

Synonyms

Tetramethylene Bis(methanesulfonate)

1,4-Butanediol Dimethylsulfonate

Tetramethylene bis[methanesulfonate]

Methanesulfonic Acid Tetramethylene Ester

1,4-Di(methylsulfonyloxy)butane

Myeloleukon

Methanesulfonic acid, tetramethylene ester

1, 4-Bis[methanesulfonoxy]butane

1,4-Di(methanesulfonyloxy)butane

1,4-Bis(methanesulfonoxy)butane

1,4-Bitanediol Dimethanesulfonate Esters

BUS

BUSULFAN

Busilvex

Bussulfam

Busulfan

Busulfanum

Busulfex

Busulphan

CB 2041

CB-2041

GT 41

GT-41

Glyzophrol

Joacamine

Mielucin

Misulban

Misulfan

Mitosan

Myeleukon

Myelosan

Mylecytan

Myleran

Sulfabutin

WR-19508

busulfan

Definitions

A synthetic derivative of dimethane-sulfonate with antineoplastic and cytotoxic properties. Although its mechanism of action is not fully understood, busulfan appears to act through the alkylation of DNA. Following systemic absorption of busulfan, carbonium ions are formed, resulting in DNA alkylation and DNA breaks and inhibition of DNA replication and RNA transcription. (NCI04)

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C321

Accepted_Therapeutic_Use_For

Bone marrow disorders; chronic myelogenous leukemia; palliative; neoadjuvant to allogeneic hematopoietic progenitor cell transplantation; neoplastic meningitis; primary brain malignancies

ALT_DEFINITION

An anticancer drug that belongs to the family of drugs called alkylating agents.

CAS_Registry

55-98-1

CHEBI_ID

CHEBI:28901

Chemical_Formula

C6H14O6S2

code

C321

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173234

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C186328

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C186327

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C174019

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C186341

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177537

Contributing_Source

CTRP

FDA

GDC

HemOnc

PCDC

DEFINITION

A synthetic derivative of dimethane-sulfonate with antineoplastic and cytotoxic properties. Although its mechanism of action is not fully understood, busulfan appears to act through the alkylation of DNA. Following systemic absorption of busulfan, carbonium ions are formed, resulting in DNA alkylation and DNA breaks and inhibition of DNA replication and RNA transcription. (NCI04)

Display_Name

Busulfan

FDA_UNII_Code

G1LN9045DK

FULL_SYN

Tetramethylene Bis(methanesulfonate)

1,4-Butanediol Dimethylsulfonate

Tetramethylene bis[methanesulfonate]

Methanesulfonic Acid Tetramethylene Ester

1,4-Di(methylsulfonyloxy)butane

Myeloleukon

Methanesulfonic acid, tetramethylene ester

1, 4-Bis[methanesulfonoxy]butane

1,4-Di(methanesulfonyloxy)butane

1,4-Bis(methanesulfonoxy)butane

1,4-Bitanediol Dimethanesulfonate Esters

BUS

BUSULFAN

Busilvex

Bussulfam

Busulfan

Busulfanum

Busulfex

Busulphan

CB 2041

CB-2041

GT 41

GT-41

Glyzophrol

Joacamine

Mielucin

Misulban

Misulfan

Mitosan

Myeleukon

Myelosan

Mylecytan

Myleran

Sulfabutin

WR-19508

busulfan

Is_PCDC_AML_Authorized_Value_For_Variable

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C274

Is_Value_For_GDC_Property

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1909

label

Busulfan

Legacy Concept Name

Busulfan

Maps_To

Busulfan

NCI_Drug_Dictionary_ID

41947

NSC Number

750

PDQ_Closed_Trial_Search_ID

41947

PDQ_Open_Trial_Search_ID

41947

Preferred_Name

Busulfan

prefixIRI

Thesaurus:C321

Semantic_Type

Organic Chemical

Pharmacologic Substance

UMLS_CUI

C0006463

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C222

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Delete Mapping To Ontology Source
http://purl.bioontology.org/ontology/LNC/LP18783-8 LOINC LOOM
http://www.gamuts.net/entity#busulfan GAMUTS LOOM
http://purl.obolibrary.org/obo/MESH_D002066 BERO LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147076 NDFRT LOOM
http://purl.obolibrary.org/obo/CHEBI_28901 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_28901 FIDEO LOOM
http://purl.obolibrary.org/obo/CHEBI_28901 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_28901 HOIP LOOM
http://purl.obolibrary.org/obo/CHEBI_28901 VDOT LOOM
http://purl.obolibrary.org/obo/CHEBI_28901 FB-CV LOOM
http://purl.obolibrary.org/obo/CHEBI_28901 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_28901 TXPO LOOM
http://purl.obolibrary.org/obo/CHEBI_28901 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_28901 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_28901 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_28901 NIFSTD LOOM
http://purl.obolibrary.org/obo/CHEBI_28901 PECO LOOM
http://purl.bioontology.org/ontology/CSP/2840-4511 CRISP LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D002066 RH-MESH LOOM
http://purl.jp/bio/4/id/200906012720303749 IOBC LOOM
http://purl.bioontology.org/ontology/NDDF/002638 NDDF LOOM
https://go.drugbank.com/drugs/DB01008 MDM LOOM
http://purl.bioontology.org/ontology/LNC/MTHU004760 LOINC LOOM
http://www.phoc.org.cn/pmo/class/PMO_00015730 PMAPP-PMO LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#2245 OCHV LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000041947 PDQ LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.033.455.125.125 RH-MESH LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387138002 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/LNC/LP416906-8 LOINC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.455.326.146.100.050.500.100 RH-MESH LOOM
http://purl.obolibrary.org/obo/OMIT_0003415 OMIT LOOM
http://purl.bioontology.org/ontology/RXNORM/1828 RXNORM LOOM
http://purl.bioontology.org/ontology/SNMI/C-78030 SNMI LOOM
http://stirdf.jst.go.jp/id/200907009861821355 IOBC LOOM
http://purl.bioontology.org/ontology/VANDF/4018773 VANDF LOOM
http://purl.bioontology.org/ontology/ATC/L01AB01 ATC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0006463 OCHV LOOM
http://purl.obolibrary.org/obo/NCIT_C321 BERO LOOM
http://purl.bioontology.org/ontology/MESH/D002066 MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.886.645.600.055.050.510.100 RH-MESH LOOM