Preferred Name |
Bleomycin |
|
Synonyms |
BLEO BLEOMYCIN BLM Bleo Bleomycin bleomycin |
|
Definitions |
A mixture of glycopeptide antineoplastic antibiotics isolated from the bacterium Streptomyces verticillus. Bleomycin forms complexes with iron that reduce molecular oxygen to superoxide and hydroxyl radicals which cause single- and double-stranded breaks in DNA; these reactive oxygen species also induce lipid peroxidation, carbohydrate oxidation, and alterations in prostaglandin synthesis and degradation. |
|
ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C313 |
|
ALT_DEFINITION |
The active ingredient in a drug that is used to treat many types of cancer and is being studied in the treatment of other types of cancer. It comes from the bacterium Streptomyces verticillus. Bleomycin damages DNA and may kill rapidly growing cancer cells. It is a type of antineoplastic antibiotic. |
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CAS_Registry |
11056-06-7 |
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CHEBI_ID |
CHEBI:3139 |
|
code |
C313 |
|
Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C186328 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C186327 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177383 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177406 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C186341 |
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Contributing_Source |
CTRP FDA GDC HemOnc PCDC |
|
DEFINITION |
A mixture of glycopeptide antineoplastic antibiotics isolated from the bacterium Streptomyces verticillus. Bleomycin forms complexes with iron that reduce molecular oxygen to superoxide and hydroxyl radicals which cause single- and double-stranded breaks in DNA; these reactive oxygen species also induce lipid peroxidation, carbohydrate oxidation, and alterations in prostaglandin synthesis and degradation. |
|
Display_Name |
Bleomycin |
|
FDA_UNII_Code |
40S1VHN69B |
|
FULL_SYN |
BLEO BLEOMYCIN BLM Bleo Bleomycin bleomycin |
|
Has_Salt_Form | ||
Is_PCDC_GCT_Authorized_Value_For_Variable | ||
Is_Value_For_GDC_Property | ||
label |
Bleomycin |
|
Legacy Concept Name |
Bleomycin |
|
Maps_To |
Bleomycin |
|
NCI_Drug_Dictionary_ID |
813324 |
|
NSC Number |
125066 |
|
Preferred_Name |
Bleomycin |
|
prefixIRI |
Thesaurus:C313 |
|
Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
UMLS_CUI |
C0005740 |
|
subClassOf |