National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Bleomycin

Synonyms

BLEO

BLEOMYCIN

BLM

Bleo

Bleomycin

bleomycin

Definitions

A mixture of glycopeptide antineoplastic antibiotics isolated from the bacterium Streptomyces verticillus. Bleomycin forms complexes with iron that reduce molecular oxygen to superoxide and hydroxyl radicals which cause single- and double-stranded breaks in DNA; these reactive oxygen species also induce lipid peroxidation, carbohydrate oxidation, and alterations in prostaglandin synthesis and degradation.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C313

ALT_DEFINITION

The active ingredient in a drug that is used to treat many types of cancer and is being studied in the treatment of other types of cancer. It comes from the bacterium Streptomyces verticillus. Bleomycin damages DNA and may kill rapidly growing cancer cells. It is a type of antineoplastic antibiotic.

CAS_Registry

11056-06-7

CHEBI_ID

CHEBI:3139

code

C313

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C186328

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C186327

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177383

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177406

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C186341

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177537

Contributing_Source

CTRP

FDA

GDC

HemOnc

PCDC

DEFINITION

A mixture of glycopeptide antineoplastic antibiotics isolated from the bacterium Streptomyces verticillus. Bleomycin forms complexes with iron that reduce molecular oxygen to superoxide and hydroxyl radicals which cause single- and double-stranded breaks in DNA; these reactive oxygen species also induce lipid peroxidation, carbohydrate oxidation, and alterations in prostaglandin synthesis and degradation.

Display_Name

Bleomycin

FDA_UNII_Code

40S1VHN69B

FULL_SYN

BLEO

BLEOMYCIN

BLM

Bleo

Bleomycin

bleomycin

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C312

Is_PCDC_GCT_Authorized_Value_For_Variable

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C274

Is_Value_For_GDC_Property

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1909

label

Bleomycin

Legacy Concept Name

Bleomycin

Maps_To

Bleomycin

NCI_Drug_Dictionary_ID

813324

NSC Number

125066

Preferred_Name

Bleomycin

prefixIRI

Thesaurus:C313

Semantic_Type

Organic Chemical

Pharmacologic Substance

UMLS_CUI

C0005740

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2311

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Delete Mapping To Ontology Source
http://purl.obolibrary.org/obo/CHEBI_22907 EFO LOOM
http://purl.org/obo/owl/CHEBI#CHEBI_22907 NPO LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/372843005 SNOMEDCT LOOM
http://purl.obolibrary.org/obo/CHEBI_22907 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_22907 FIDEO LOOM
http://purl.obolibrary.org/obo/CHEBI_22907 HOIP LOOM
http://purl.obolibrary.org/obo/CHEBI_22907 COVID-19 LOOM
http://purl.obolibrary.org/obo/CHEBI_22907 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_22907 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_22907 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_22907 OBA LOOM
http://purl.obolibrary.org/obo/CHEBI_22907 FYPO LOOM
http://purl.obolibrary.org/obo/CHEBI_22907 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_22907 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_22907 PHIPO LOOM
http://purl.obolibrary.org/obo/CHEBI_22907 GENEPIO LOOM
http://purl.obolibrary.org/obo/CHEBI_22907 GO-PLUS LOOM
http://purl.bioontology.org/ontology/RXNORM/1622 RXNORM LOOM
http://purl.obolibrary.org/obo/NCIT_C313 BERO LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147730 NDFRT LOOM
http://purl.obolibrary.org/obo/ARO_0000053 ARO LOOM
http://purl.jp/bio/4/id/200906064494945155 IOBC LOOM
http://purl.bioontology.org/ontology/ATC/L01DC01 ATC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D09.400.420.110 RH-MESH LOOM
https://go.drugbank.com/drugs/DB00290 MDM LOOM
http://www.drugbank.ca/drugs/DB00290 FTC LOOM
http://purl.bioontology.org/ontology/SNMI/C-78020 SNMI LOOM
http://www.phoc.org.cn/pmo/class/PMO_00020936 PMAPP-PMO LOOM
http://purl.obolibrary.org/obo/dinto_DB00290 DINTO LOOM
http://purl.obolibrary.org/obo/MESH_D001761 BERO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D12.644.233.110 RH-MESH LOOM
http://purl.obolibrary.org/obo/OMIT_0003121 OMIT LOOM
http://purl.bioontology.org/ontology/RCD/h22.. RCD LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#1968 OCHV LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0005740 OCHV LOOM
http://www.gamuts.net/entity#bleomycin GAMUTS LOOM
http://stirdf.jst.go.jp/id/200907068334492625 IOBC LOOM
http://purl.bioontology.org/ontology/VANDF/4019637 VANDF LOOM
http://purl.bioontology.org/ontology/CSP/0192-9722 CRISP LOOM
http://purl.bioontology.org/ontology/MESH/D001761 MESH LOOM
http://purl.obolibrary.org/obo/XCO_0001298 XCO LOOM
http://www.co-ode.org/ontologies/galen#Bleomycin GALEN LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D001761 RH-MESH LOOM