Preferred Name

Bleomycin

Synonyms

bleomycin

Bleomycin

BLM

Bleo

BLEO

BLEOMYCIN

Definitions

A mixture of glycopeptide antineoplastic antibiotics isolated from the bacterium Streptomyces verticillus. Bleomycin forms complexes with iron that reduce molecular oxygen to superoxide and hydroxyl radicals which cause single- and double-stranded breaks in DNA; these reactive oxygen species also induce lipid peroxidation, carbohydrate oxidation, and alterations in prostaglandin synthesis and degradation.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C313

ALT_DEFINITION

The active ingredient in a drug that is used to treat many types of cancer and is being studied in the treatment of other types of cancer. It comes from the bacterium Streptomyces verticillus. Bleomycin damages DNA and may kill rapidly growing cancer cells. It is a type of antineoplastic antibiotic.

CAS_Registry

11056-06-7

CHEBI_ID

CHEBI:3139

code

C313

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

Contributing_Source

CTRP

FDA

DEFINITION

A mixture of glycopeptide antineoplastic antibiotics isolated from the bacterium Streptomyces verticillus. Bleomycin forms complexes with iron that reduce molecular oxygen to superoxide and hydroxyl radicals which cause single- and double-stranded breaks in DNA; these reactive oxygen species also induce lipid peroxidation, carbohydrate oxidation, and alterations in prostaglandin synthesis and degradation.

Display_Name

Bleomycin

FDA_UNII_Code

40S1VHN69B

FULL_SYN

bleomycin

Bleomycin

BLM

Bleo

BLEO

BLEOMYCIN

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C312

label

Bleomycin

Legacy_Concept_Name

Bleomycin

NSC_Code

125066

Preferred_Name

Bleomycin

prefixIRI

ncit:C313

Semantic_Type

Organic Chemical

Antibiotic

UMLS_CUI

C0005740

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2311

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http://phenomebrowser.net/ontologies/mesh/mesh.owl#D12.644.233.110 RH-MESH LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/372843005 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/UATC/L01DC01 ATC LOOM
http://purl.jp/bio/4/id/200906064494945155 IOBC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D09.400.420.110 RH-MESH LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147730 NDFRT LOOM
http://purl.org/obo/owl/CHEBI#CHEBI_22907 NPO LOOM
http://purl.obolibrary.org/obo/dinto_DB00290 DINTO LOOM
http://www.drugbank.ca/drugs/DB00290 FTC LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000039139 PDQ LOOM
http://purl.obolibrary.org/obo/CHEBI_22907 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_22907 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_22907 GENEPIO LOOM
http://purl.obolibrary.org/obo/CHEBI_22907 FYPO LOOM
http://purl.obolibrary.org/obo/CHEBI_22907 CCONT LOOM
http://purl.obolibrary.org/obo/CHEBI_22907 FYPO LOOM
http://purl.obolibrary.org/obo/CHEBI_22907 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_22907 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_22907 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_22907 FYPO LOOM
http://purl.obolibrary.org/obo/CHEBI_22907 FYPO LOOM
http://purl.obolibrary.org/obo/CHEBI_22907 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_22907 FYPO LOOM
http://purl.obolibrary.org/obo/CHEBI_22907 CHEBI LOOM
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http://purl.bioontology.org/ontology/CSP/0192-9722 CRISP LOOM
http://id.loc.gov/authorities/subjects/sh85014840 FAST-TOPICAL LOOM
http://purl.bioontology.org/ontology/RXNORM/1622 RXNORM LOOM
http://www.co-ode.org/ontologies/galen#Bleomycin GALEN LOOM
http://purl.bioontology.org/ontology/MESH/D001761 MESH LOOM
http://purl.bioontology.org/ontology/VANDF/4019637 VANDF LOOM
http://stirdf.jst.go.jp/id/200907068334492625 IOBC LOOM
http://d-nb.info/gnd/4209363-6 FAST-TOPICAL LOOM
http://purl.bioontology.org/ontology/RCD/h22.. RCD LOOM
http://purl.bioontology.org/ontology/SNMI/C-78020 SNMI LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D001761 RH-MESH LOOM