Preferred Name |
Nimesulide |
|
Synonyms |
N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide NIMESULIDE Nimesulide |
|
Definitions |
A nonsteroidal arylsulfonamide with anti-inflammatory properties. Nimesulide inhibits the cyclooxygenase-mediated conversion of arachidonic acid to pro-inflammatory prostaglandins. Modestly selective for COX-2, this agent binds to the enzyme, thereby inactivating it. Nimesulide may inhibit some carcinogenic COX-2-related carcinogenic effects on xenobiotic metabolism, apoptosis, immune surveillance and angiogenesis (overexpressed COX-2 in tumor epithelial cells enhances production of vascular growth factors and the formation of capillary-like networks). (NCI04) |
|
ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29842 |
|
CAS_Registry |
51803-78-2 |
|
CHEBI_ID |
CHEBI:44445 |
|
Chemical_Formula |
C13H12N2O5S |
|
code |
C29842 |
|
Concept_In_Subset | ||
Contributing_Source |
FDA |
|
DEFINITION |
A nonsteroidal arylsulfonamide with anti-inflammatory properties. Nimesulide inhibits the cyclooxygenase-mediated conversion of arachidonic acid to pro-inflammatory prostaglandins. Modestly selective for COX-2, this agent binds to the enzyme, thereby inactivating it. Nimesulide may inhibit some carcinogenic COX-2-related carcinogenic effects on xenobiotic metabolism, apoptosis, immune surveillance and angiogenesis (overexpressed COX-2 in tumor epithelial cells enhances production of vascular growth factors and the formation of capillary-like networks). (NCI04) |
|
FDA_UNII_Code |
V4TKW1454M |
|
FULL_SYN |
N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide NIMESULIDE Nimesulide |
|
label |
Nimesulide |
|
Legacy Concept Name |
Nimesulide |
|
Preferred_Name |
Nimesulide |
|
prefixIRI |
Thesaurus:C29842 |
|
Semantic_Type |
Pharmacologic Substance |
|
UMLS_CUI |
C0132515 |
|
subClassOf |