National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Nimesulide

Synonyms

N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide

NIMESULIDE

Nimesulide

Definitions

A nonsteroidal arylsulfonamide with anti-inflammatory properties. Nimesulide inhibits the cyclooxygenase-mediated conversion of arachidonic acid to pro-inflammatory prostaglandins. Modestly selective for COX-2, this agent binds to the enzyme, thereby inactivating it. Nimesulide may inhibit some carcinogenic COX-2-related carcinogenic effects on xenobiotic metabolism, apoptosis, immune surveillance and angiogenesis (overexpressed COX-2 in tumor epithelial cells enhances production of vascular growth factors and the formation of capillary-like networks). (NCI04)

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29842

CAS_Registry

51803-78-2

CHEBI_ID

CHEBI:44445

Chemical_Formula

C13H12N2O5S

code

C29842

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A nonsteroidal arylsulfonamide with anti-inflammatory properties. Nimesulide inhibits the cyclooxygenase-mediated conversion of arachidonic acid to pro-inflammatory prostaglandins. Modestly selective for COX-2, this agent binds to the enzyme, thereby inactivating it. Nimesulide may inhibit some carcinogenic COX-2-related carcinogenic effects on xenobiotic metabolism, apoptosis, immune surveillance and angiogenesis (overexpressed COX-2 in tumor epithelial cells enhances production of vascular growth factors and the formation of capillary-like networks). (NCI04)

FDA_UNII_Code

V4TKW1454M

FULL_SYN

N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide

NIMESULIDE

Nimesulide

label

Nimesulide

Legacy Concept Name

Nimesulide

Preferred_Name

Nimesulide

prefixIRI

Thesaurus:C29842

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0132515

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1323

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