National Cancer Institute Thesaurus

Last uploaded: February 23, 2024

Preferred Name	Sulfonamide Anti-Infective Agent
Synonyms	Sulfonamides Sulfonamide Anti-Infective Agent sulfonamide sulfa drug
Definitions	A class of natural or synthetic sulfanilamide derivatives with antibacterial activity. Sulfonamides are structural analogs of para-aminobenzoic acid (essential for microbial folate synthesis). Sulfonamides inhibit bacterial metabolism by competing with PABA for dihydropteroate synthase, thereby resulting in disruption of folic acid metabolism and ultimately DNA synthesis.
ID	http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29739
ALT_DEFINITION	A type of antibiotic used to treat infection.
code	C29739
DEFINITION	A class of natural or synthetic sulfanilamide derivatives with antibacterial activity. Sulfonamides are structural analogs of para-aminobenzoic acid (essential for microbial folate synthesis). Sulfonamides inhibit bacterial metabolism by competing with PABA for dihydropteroate synthase, thereby resulting in disruption of folic acid metabolism and ultimately DNA synthesis.
FULL_SYN	Sulfonamides Sulfonamide Anti-Infective Agent sulfonamide sulfa drug
label	Sulfonamide Anti-Infective Agent
Legacy Concept Name	Sulfonamide_Anti-infective_Agent
NCI_META_CUI	CL557618
Preferred_Name	Sulfonamide Anti-Infective Agent
prefixIRI	Thesaurus:C29739
Semantic_Type	Chemical Viewed Functionally
subClassOf	http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C254

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Delete	Mapping To	Ontology	Source
	http://purl.obolibrary.org/obo/NCIT_C29739	BERO	LOOM