National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Valproic Acid

Synonyms

valproic acid

2-Propylpentanoic Acid

VALPROIC ACID

Valproic Acid

Di-n-propylacetic Acid

2-Propylvaleric Acid

Depakene

Stavzor

Valproate

Definitions

A synthetic derivative of propylpentanoic acid with antiepileptic properties and potential antineoplastic and antiangiogenesis activities. In epilepsy, valproic acid appears to act by increasing the concentration of gamma-aminobutyric acid (GABA) in the brain. This agent's antitumor and antiangiogenesis activities may be related to the inhibition of histone deacetylases and nitric oxide synthase, which results in the inhibition of nitric oxide synthesis. (NCI04)

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29536

Accepted_Therapeutic_Use_For

Epilepsy; Mania; Migraine

ALT_DEFINITION

A drug used to treat epileptic seizures and bipolar disorder and to prevent migraine headaches. It is also being studied in the treatment of several types of cancer. It blocks an enzyme that cells need to grow and may cause cancer cells to die. It also blocks the growth of new blood vessels that tumors need to grow. It is a type of anticonvulsant, histone deacetylase (HDAC) inhibitor, antimaniacal, migraine headache prophylactic, and antiangiogenesis agent.

CAS_Registry

99-66-1

CHEBI_ID

CHEBI:39867

Chemical_Formula

C8H16O2

code

C29536

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177537

Contributing_Source

CTRP

FDA

GDC

DEFINITION

A synthetic derivative of propylpentanoic acid with antiepileptic properties and potential antineoplastic and antiangiogenesis activities. In epilepsy, valproic acid appears to act by increasing the concentration of gamma-aminobutyric acid (GABA) in the brain. This agent's antitumor and antiangiogenesis activities may be related to the inhibition of histone deacetylases and nitric oxide synthase, which results in the inhibition of nitric oxide synthesis. (NCI04)

Display_Name

Valproic Acid

FDA_UNII_Code

614OI1Z5WI

FULL_SYN

valproic acid

2-Propylpentanoic Acid

VALPROIC ACID

Valproic Acid

Di-n-propylacetic Acid

2-Propylvaleric Acid

Depakene

Stavzor

Valproate

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C71156

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C48029

Is_Value_For_GDC_Property

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1909

label

Valproic Acid

Legacy Concept Name

Valproic_Acid

Maps_To

Valproic Acid

NCI_Drug_Dictionary_ID

350047

NSC Number

93819

PDQ_Closed_Trial_Search_ID

350047

PDQ_Open_Trial_Search_ID

350047

Preferred_Name

Valproic Acid

prefixIRI

Thesaurus:C29536

Semantic_Type

Organic Chemical

Pharmacologic Substance

UMLS_CUI

C0042291

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C264

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Delete Mapping To Ontology Source
http://www.case.edu/EpilepsyOntology.owl#ValproicAcid EPSO LOOM
http://purl.obolibrary.org/obo/CHEBI_39867 FYPO LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387080000 SNOMEDCT LOOM
http://www.case.edu/EpSO.owl#ValproicAcid MEPO LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0042291 OCHV LOOM
http://purl.obolibrary.org/obo/CHEBI_39867 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_39867 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_39867 FIDEO LOOM
http://purl.obolibrary.org/obo/CHEBI_39867 OBI LOOM
http://purl.obolibrary.org/obo/CHEBI_39867 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_39867 HOIP LOOM
http://purl.obolibrary.org/obo/CHEBI_39867 COVID-19 LOOM
http://purl.obolibrary.org/obo/CHEBI_39867 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_39867 TXPO LOOM
http://purl.obolibrary.org/obo/CHEBI_39867 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_39867 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_39867 FYPO LOOM
http://purl.obolibrary.org/obo/CHEBI_39867 CIDO LOOM
http://purl.obolibrary.org/obo/CHEBI_39867 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_39867 NIFSTD LOOM
http://purl.obolibrary.org/obo/OMIT_0015469 OMIT LOOM
http://purl.bioontology.org/ontology/ATC/N03AG01 ATC LOOM
http://purl.bioontology.org/ontology/MESH/D014635 MESH LOOM
http://purl.bioontology.org/ontology/VANDF/4018723 VANDF LOOM
http://stirdf.jst.go.jp/id/200907057055574563 IOBC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D014635 RH-MESH LOOM
http://doe-generated-ontology.com/OntoAD#C0042291 ONTOAD LOOM
http://purl.jp/bio/4/id/200906053586959002 IOBC LOOM
http://ontology.apa.org/apaonto/termsonlyOUT%20(5).owl#Valproic_Acid APAONTO LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#12885 OCHV LOOM
http://purl.bioontology.org/ontology/SNMI/C-61132 SNMI LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000350047 PDQ LOOM
http://purl.bioontology.org/ontology/RXNORM/11118 RXNORM LOOM
http://purl.obolibrary.org/obo/NCIT_C29536 BERO LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147028 NDFRT LOOM
http://www.semanticweb.org/cjf/ontologies/2022/8/NeuralReprogrammingOntology(NRO)#Valproic_acid NRO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.241.081.944.509.900 RH-MESH LOOM
http://www.phoc.org.cn/pmo/class/PMO_00016455 PMAPP-PMO LOOM
https://go.drugbank.com/drugs/DB00313 MDM LOOM
http://purl.bioontology.org/ontology/NDDF/001622 NDDF LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D10.251.400.895.593.900 RH-MESH LOOM
http://purl.bioontology.org/ontology/RCD/dnh.. RCD LOOM
http://www.drugbank.ca/drugs/DB00313 FTC LOOM
http://www.semanticweb.org/ftuha/ontologies/2021/5/FRMO-01untitled-ontology-175/Valproic_Acid FRMO LOOM
https://bioportal.bioontology.org/ontologies/STMSO#Valproic_acid STMSO LOOM
http://purl.obolibrary.org/obo/MESH_D014635 BERO LOOM