National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Tolmetin

Synonyms

TOLMETIN

Tolmetin

Definitions

An arylalkanoic acid and non-steroidal anti-inflammatory drug (NSAID) with analgesic, anti-inflammatory and antipyretic activities. Although the exact mechanism through which tolmetin exerts its effects has yet to be fully elucidated, this agent appears to inhibit the enzyme prostaglandin synthase. This prevents the formation of prostaglandins from prostaglandin precursors, including the synthesis of the inflammatory prostaglandin E2 (PGE2) from the precursor prostaglandin H2 (PGH2). This prevents prostaglandin-mediated effects, including pain, inflammation and fever.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29503

CAS_Registry

26171-23-3

Chemical_Formula

C15H15NO3

code

C29503

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

An arylalkanoic acid and non-steroidal anti-inflammatory drug (NSAID) with analgesic, anti-inflammatory and antipyretic activities. Although the exact mechanism through which tolmetin exerts its effects has yet to be fully elucidated, this agent appears to inhibit the enzyme prostaglandin synthase. This prevents the formation of prostaglandins from prostaglandin precursors, including the synthesis of the inflammatory prostaglandin E2 (PGE2) from the precursor prostaglandin H2 (PGH2). This prevents prostaglandin-mediated effects, including pain, inflammation and fever.

FDA_UNII_Code

D8K2JPN18B

FULL_SYN

TOLMETIN

Tolmetin

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61977

label

Tolmetin

Legacy Concept Name

Tolmetin

Preferred_Name

Tolmetin

prefixIRI

Thesaurus:C29503

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0040377

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C257

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http://www.drugbank.ca/drugs/DB00500 FTC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D014046 RH-MESH LOOM
http://www.phoc.org.cn/pmo/class/PMO_00018232 PMAPP-PMO LOOM
http://purl.bioontology.org/ontology/LNC/LP18114-6 LOINC LOOM
http://purl.bioontology.org/ontology/LNC/MTHU003398 LOINC LOOM
http://purl.bioontology.org/ontology/RXNORM/10636 RXNORM LOOM
http://purl.obolibrary.org/obo/DRON_00011680 ODNAE LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/372748008 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/ATC/M01AB03 ATC LOOM
http://purl.bioontology.org/ontology/ATC/M02AA21 ATC LOOM
http://www.co-ode.org/ontologies/galen#Tolmetin GALEN LOOM
http://purl.bioontology.org/ontology/VANDF/4019952 VANDF LOOM
http://purl.obolibrary.org/obo/NCIT_C29503 BERO LOOM
http://stirdf.jst.go.jp/id/200907016243540210 IOBC LOOM
http://purl.obolibrary.org/obo/CHEBI_71941 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_71941 FIDEO LOOM
http://purl.obolibrary.org/obo/CHEBI_71941 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_71941 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_71941 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_71941 CHEBI LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.383.129.578.910 RH-MESH LOOM
http://purl.obolibrary.org/obo/MESH_D014046 BERO LOOM
http://purl.bioontology.org/ontology/SNMI/C-60450 SNMI LOOM
http://purl.obolibrary.org/obo/OMIT_0014887 OMIT LOOM
http://purl.bioontology.org/ontology/RCD/j2h.. RCD LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0040377 OCHV LOOM
http://scai.fraunhofer.de/AlzheimerOntology#tolmetin ADO LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#12341 OCHV LOOM
http://purl.bioontology.org/ontology/NDDF/004811 NDDF LOOM
https://go.drugbank.com/drugs/DB00500 MDM LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148037 NDFRT LOOM
http://purl.bioontology.org/ontology/MESH/D014046 MESH LOOM
http://purl.jp/bio/4/id/200906041190595972 IOBC LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000148037 ODAE LOOM