loading...| Preferred Name |
Bacitracin |
| Synonyms |
BACITRACIN Bacitracin |
| Definitions |
A complex of cyclic polypeptide antibiotics, mainly bacitracin A, produced by spore-forming organisms belonging to the licheniformin group of the Bacillus subtilis with antibacterial activity. Bacitracin binds to C55-isoprenyl pyrophosphate, a biphosphate lipid transport molecule that carries the building blocks of the peptidoglycan bacterial cell wall. The binding interferes with the enzymatic dephosphorylation of the C55-isoprenyl pyrophosphate and prevents peptidoglycan synthesis, thereby inhibiting bacterial cell growth. |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C295 |
| CAS_Registry |
1405-87-4 |
| CHEBI_ID |
CHEBI:28669 |
| code |
C295 |
| Concept_In_Subset | |
| Contributing_Source |
FDA |
| DEFINITION |
A complex of cyclic polypeptide antibiotics, mainly bacitracin A, produced by spore-forming organisms belonging to the licheniformin group of the Bacillus subtilis with antibacterial activity. Bacitracin binds to C55-isoprenyl pyrophosphate, a biphosphate lipid transport molecule that carries the building blocks of the peptidoglycan bacterial cell wall. The binding interferes with the enzymatic dephosphorylation of the C55-isoprenyl pyrophosphate and prevents peptidoglycan synthesis, thereby inhibiting bacterial cell growth. |
| FDA_UNII_Code |
58H6RWO52I |
| FULL_SYN |
BACITRACIN Bacitracin |
| Has_Salt_Form | |
| label |
Bacitracin |
| Legacy_Concept_Name |
Bacitracin |
| NSC_Code |
45737 |
| PDQ_Closed_Trial_Search_ID |
42858 |
| PDQ_Open_Trial_Search_ID |
42858 |
| Preferred_Name |
Bacitracin |
| prefixIRI |
ncit:C295 |
| Semantic_Type |
Amino Acid, Peptide, or Protein Antibiotic |
| UMLS_CUI |
C0004599 |
| subClassOf |