Preferred Name |
Bacitracin |
Synonyms |
BACITRACIN Bacitracin |
Definitions |
A complex of cyclic polypeptide antibiotics, mainly bacitracin A, produced by spore-forming organisms belonging to the licheniformin group of the Bacillus subtilis with antibacterial activity. Bacitracin binds to C55-isoprenyl pyrophosphate, a biphosphate lipid transport molecule that carries the building blocks of the peptidoglycan bacterial cell wall. The binding interferes with the enzymatic dephosphorylation of the C55-isoprenyl pyrophosphate and prevents peptidoglycan synthesis, thereby inhibiting bacterial cell growth. |
ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C295 |
CAS_Registry |
1405-87-4 |
CHEBI_ID |
CHEBI:28669 |
code |
C295 |
Concept_In_Subset | |
Contributing_Source |
FDA |
DEFINITION |
A complex of cyclic polypeptide antibiotics, mainly bacitracin A, produced by spore-forming organisms belonging to the licheniformin group of the Bacillus subtilis with antibacterial activity. Bacitracin binds to C55-isoprenyl pyrophosphate, a biphosphate lipid transport molecule that carries the building blocks of the peptidoglycan bacterial cell wall. The binding interferes with the enzymatic dephosphorylation of the C55-isoprenyl pyrophosphate and prevents peptidoglycan synthesis, thereby inhibiting bacterial cell growth. |
FDA_UNII_Code |
58H6RWO52I |
FULL_SYN |
BACITRACIN Bacitracin |
Has_Salt_Form | |
label |
Bacitracin |
Legacy_Concept_Name |
Bacitracin |
NSC_Code |
45737 |
PDQ_Closed_Trial_Search_ID |
42858 |
PDQ_Open_Trial_Search_ID |
42858 |
Preferred_Name |
Bacitracin |
prefixIRI |
ncit:C295 |
Semantic_Type |
Amino Acid, Peptide, or Protein Antibiotic |
UMLS_CUI |
C0004599 |
subClassOf |