National Cancer Institute Thesaurus

Last uploaded: September 30, 2019
Preferred Name

Bacitracin

Synonyms

BACITRACIN

Bacitracin

Definitions

A complex of cyclic polypeptide antibiotics, mainly bacitracin A, produced by spore-forming organisms belonging to the licheniformin group of the Bacillus subtilis with antibacterial activity. Bacitracin binds to C55-isoprenyl pyrophosphate, a biphosphate lipid transport molecule that carries the building blocks of the peptidoglycan bacterial cell wall. The binding interferes with the enzymatic dephosphorylation of the C55-isoprenyl pyrophosphate and prevents peptidoglycan synthesis, thereby inhibiting bacterial cell growth.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C295

CAS_Registry

1405-87-4

CHEBI_ID

CHEBI:28669

code

C295

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A complex of cyclic polypeptide antibiotics, mainly bacitracin A, produced by spore-forming organisms belonging to the licheniformin group of the Bacillus subtilis with antibacterial activity. Bacitracin binds to C55-isoprenyl pyrophosphate, a biphosphate lipid transport molecule that carries the building blocks of the peptidoglycan bacterial cell wall. The binding interferes with the enzymatic dephosphorylation of the C55-isoprenyl pyrophosphate and prevents peptidoglycan synthesis, thereby inhibiting bacterial cell growth.

FDA_UNII_Code

58H6RWO52I

FULL_SYN

BACITRACIN

Bacitracin

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28857

label

Bacitracin

Legacy_Concept_Name

Bacitracin

NSC_Code

45737

PDQ_Closed_Trial_Search_ID

42858

PDQ_Open_Trial_Search_ID

42858

Preferred_Name

Bacitracin

prefixIRI

ncit:C295

Semantic_Type

Amino Acid, Peptide, or Protein

Antibiotic

UMLS_CUI

C0004599

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C258

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http://www.co-ode.org/ontologies/galen#Bacitracin GALEN LOOM
http://purl.bioontology.org/ontology/RCD/X79H1 RCD LOOM
http://purl.obolibrary.org/obo/UPa_UPC01667 UPA LOOM
http://purl.bioontology.org/ontology/UATC/J01XX10 ATC LOOM
http://purl.jp/bio/4/id/200906017725543588 IOBC LOOM
http://purl.bioontology.org/ontology/RXNORM/1291 RXNORM LOOM
http://purl.bioontology.org/ontology/UATC/R02AB04 ATC LOOM
http://purl.bioontology.org/ontology/UATC/D06AX05 ATC LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000145879 NDFRT LOOM
http://purl.bioontology.org/ontology/MESH/D001414 MESH LOOM
http://purl.bioontology.org/ontology/NDDF/002798 NDDF LOOM
http://purl.obolibrary.org/obo/ARO_0000041 ARO LOOM
http://purl.obolibrary.org/obo/ARO_0000041 ARO LOOM
http://purl.obolibrary.org/obo/CHEBI_28669 PHIPO LOOM
http://purl.obolibrary.org/obo/CHEBI_28669 PHIPO LOOM
http://purl.obolibrary.org/obo/CHEBI_28669 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_28669 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_28669 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_28669 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_28669 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_28669 NIFSTD LOOM
http://purl.bioontology.org/ontology/LNC/LP14906-9 LOINC LOOM
http://purl.obolibrary.org/obo/dinto_DB00626 DINTO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D12.644.641.075 RH-MESH LOOM
http://d-nb.info/gnd/4143854-1 FAST-TOPICAL LOOM
http://www.drugbank.ca/drugs/DB00626 FTC LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000042858 PDQ LOOM
http://purl.bioontology.org/ontology/VANDF/4017493 VANDF LOOM
http://purl.bioontology.org/ontology/LNC/MTHU002155 LOINC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0004599 OCHV LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D001414 RH-MESH LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/5220000 SNOMEDCT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D04.345.566.075 RH-MESH LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#1659 OCHV LOOM