loading...| Preferred Name |
Tenecteplase |
|
| Synonyms |
TENECTEPLASE Tenecteplase TNK-tPA TNKase |
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| Definitions |
A 527 amino acid glycoprotein and the modified form of the naturally occurring human plasminogen activator (tPA) with tissue plasminogen activating activity. Tenecteplase (TNKase) is a serine protease created by introducing substitutions of threonine 103 with asparagine, asparagine 117 with glutamine within the kringle 1 domain, and a tetra-alanine substitution at amino acids 296-299 in the protease domain. TNKase converts fibrin-bound plasminogen to plasmin by cleaving the Arg/Val bond in plasminogen. Plasmin in turn degrades the fibrin matrix of the thrombus mass, thereby helps eliminate blood clots or arterial blockages that cause myocardial infarction. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29489 |
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| CAS_Registry |
191588-94-0 |
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| code |
C29489 |
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C173381 |
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| Contributing_Source |
FDA |
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| DEFINITION |
A 527 amino acid glycoprotein and the modified form of the naturally occurring human plasminogen activator (tPA) with tissue plasminogen activating activity. Tenecteplase (TNKase) is a serine protease created by introducing substitutions of threonine 103 with asparagine, asparagine 117 with glutamine within the kringle 1 domain, and a tetra-alanine substitution at amino acids 296-299 in the protease domain. TNKase converts fibrin-bound plasminogen to plasmin by cleaving the Arg/Val bond in plasminogen. Plasmin in turn degrades the fibrin matrix of the thrombus mass, thereby helps eliminate blood clots or arterial blockages that cause myocardial infarction. |
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| FDA_UNII_Code |
WGD229O42W |
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| FULL_SYN |
TENECTEPLASE Tenecteplase TNK-tPA TNKase |
|
| label |
Tenecteplase |
|
| Legacy Concept Name |
Tenecteplase |
|
| Preferred_Name |
Tenecteplase |
|
| prefixIRI |
Thesaurus:C29489 |
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| Semantic_Type |
Amino Acid, Peptide, or Protein Pharmacologic Substance |
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| UMLS_CUI |
C0872913 |
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| subClassOf |