National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Tazarotene

Synonyms

6-[(3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl)ethynyl]- 3-Pyridinecarboxylic Acid, Ethyl Ester

Ethyl 6-(2-(4,4-Dimethylthiochroman-6-yl)ethynyl)nicotinate

AGN-190168

Avage

TAZAROTENE

Tazarotene

Tazorac

tazarotene

Definitions

A synthetic, topical retinoid. Tazarotene induces the expression of tazarotene-induced gene 3 (TIG3), a tumor suppressor gene. In psoriasis, tazarotene normalizes abnormal keratinocyte differentiation and reduces their hyperproliferation. (NCI04)

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29487

Accepted_Therapeutic_Use_For

Topical treatment of facial acne vulgaris; stable plaque psoriasis; mitigation (palliation) of facial fine wrinkling; facial mottled hyper- and hypopigmentation; benign facial lentigines

ALT_DEFINITION

A drug used on the skin to treat several skin conditions. It is also being studied in the treatment of basal cell skin cancer and basal cell nevus syndrome. Tazarotene is related to vitamin A and is made in the laboratory. It turns on a gene that may help stop the growth of skin cancer cells. Tazarotene is a type of synthetic retinoid.

CAS_Registry

118292-40-3

CHEBI_ID

CHEBI:32184

Chemical_Formula

C21H21NO2S

code

C29487

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177537

Contributing_Source

CTRP

FDA

GDC

DEFINITION

A synthetic, topical retinoid. Tazarotene induces the expression of tazarotene-induced gene 3 (TIG3), a tumor suppressor gene. In psoriasis, tazarotene normalizes abnormal keratinocyte differentiation and reduces their hyperproliferation. (NCI04)

Display_Name

Tazarotene

FDA_UNII_Code

81BDR9Y8PS

FULL_SYN

6-[(3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl)ethynyl]- 3-Pyridinecarboxylic Acid, Ethyl Ester

Ethyl 6-(2-(4,4-Dimethylthiochroman-6-yl)ethynyl)nicotinate

AGN-190168

Avage

TAZAROTENE

Tazarotene

Tazorac

tazarotene

Is_Value_For_GDC_Property

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1909

label

Tazarotene

Legacy Concept Name

Tazarotene

Maps_To

Tazarotene

NCI_Drug_Dictionary_ID

553530

PDQ_Closed_Trial_Search_ID

553530

PDQ_Open_Trial_Search_ID

553530

Preferred_Name

Tazarotene

prefixIRI

Thesaurus:C29487

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0288792

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C804

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Delete Mapping To Ontology Source
http://purl.bioontology.org/ontology/SNOMEDCT/386935009 SNOMEDCT LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#27756 OCHV LOOM
http://www.drugbank.ca/drugs/DB00799 FTC LOOM
http://www.co-ode.org/ontologies/galen#Tazarotene GALEN LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C086827 RH-MESH LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0288792 OCHV LOOM
http://purl.bioontology.org/ontology/RXNORM/83947 RXNORM LOOM
http://purl.bioontology.org/ontology/NDDF/006668 NDDF LOOM
http://purl.obolibrary.org/obo/CHEBI_32184 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_32184 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_32184 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_32184 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_32184 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_32184 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_32184 NIFSTD LOOM
http://purl.bioontology.org/ontology/ATC/D05AX05 ATC LOOM
https://go.drugbank.com/drugs/DB00799 MDM LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000553530 PDQ LOOM
http://purl.bioontology.org/ontology/RCD/m5C.. RCD LOOM
http://stirdf.jst.go.jp/id/200907030013638221 IOBC LOOM
http://purl.jp/bio/4/id/200906086708055016 IOBC LOOM
http://purl.obolibrary.org/obo/NCIT_C29487 BERO LOOM
http://purl.bioontology.org/ontology/VANDF/4021045 VANDF LOOM
http://purl.bioontology.org/ontology/MESH/C086827 MESH LOOM
http://www.phoc.org.cn/pmo/class/PMO_00025753 PMAPP-PMO LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148509 NDFRT LOOM