Preferred Name |
Tazarotene |
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Synonyms |
6-[(3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl)ethynyl]- 3-Pyridinecarboxylic Acid, Ethyl Ester Ethyl 6-(2-(4,4-Dimethylthiochroman-6-yl)ethynyl)nicotinate AGN-190168 Avage TAZAROTENE Tazarotene Tazorac tazarotene |
|
Definitions |
A synthetic, topical retinoid. Tazarotene induces the expression of tazarotene-induced gene 3 (TIG3), a tumor suppressor gene. In psoriasis, tazarotene normalizes abnormal keratinocyte differentiation and reduces their hyperproliferation. (NCI04) |
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ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29487 |
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Accepted_Therapeutic_Use_For |
Topical treatment of facial acne vulgaris; stable plaque psoriasis; mitigation (palliation) of facial fine wrinkling; facial mottled hyper- and hypopigmentation; benign facial lentigines |
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ALT_DEFINITION |
A drug used on the skin to treat several skin conditions. It is also being studied in the treatment of basal cell skin cancer and basal cell nevus syndrome. Tazarotene is related to vitamin A and is made in the laboratory. It turns on a gene that may help stop the growth of skin cancer cells. Tazarotene is a type of synthetic retinoid. |
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CAS_Registry |
118292-40-3 |
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CHEBI_ID |
CHEBI:32184 |
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Chemical_Formula |
C21H21NO2S |
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code |
C29487 |
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Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784 |
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Contributing_Source |
CTRP FDA GDC |
|
DEFINITION |
A synthetic, topical retinoid. Tazarotene induces the expression of tazarotene-induced gene 3 (TIG3), a tumor suppressor gene. In psoriasis, tazarotene normalizes abnormal keratinocyte differentiation and reduces their hyperproliferation. (NCI04) |
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Display_Name |
Tazarotene |
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FDA_UNII_Code |
81BDR9Y8PS |
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FULL_SYN |
6-[(3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl)ethynyl]- 3-Pyridinecarboxylic Acid, Ethyl Ester Ethyl 6-(2-(4,4-Dimethylthiochroman-6-yl)ethynyl)nicotinate AGN-190168 Avage TAZAROTENE Tazarotene Tazorac tazarotene |
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Is_Value_For_GDC_Property | ||
label |
Tazarotene |
|
Legacy Concept Name |
Tazarotene |
|
Maps_To |
Tazarotene |
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NCI_Drug_Dictionary_ID |
553530 |
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PDQ_Closed_Trial_Search_ID |
553530 |
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PDQ_Open_Trial_Search_ID |
553530 |
|
Preferred_Name |
Tazarotene |
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prefixIRI |
Thesaurus:C29487 |
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Semantic_Type |
Pharmacologic Substance |
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UMLS_CUI |
C0288792 |
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subClassOf |