National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Ranitidine

Synonyms

N-[2-[[[5-[(Dimethylamino)methyl]-2-furanyl]methyl]thio]ethyl]-N'-methyl-2-nitro-1,1-ethenediamine

RANITIDINE

Ranitidine

Definitions

A member of the class of histamine H2-receptor antagonists with antacid activity. Ranitidine is a competitive and reversible inhibitor of the action of histamine, released by enterochromaffin-like (ECL) cells, at the histamine H2-receptors on parietal cells in the stomach, thereby inhibiting the normal and meal-stimulated secretion of stomach acid. In addition, other substances that promote acid secretion have a reduced effect on parietal cells when the H2 receptors are blocked.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29412

CAS_Registry

66357-35-5

CHEBI_ID

CHEBI:8776

Chemical_Formula

C13H22N4O3S

code

C29412

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

HemOnc

DEFINITION

A member of the class of histamine H2-receptor antagonists with antacid activity. Ranitidine is a competitive and reversible inhibitor of the action of histamine, released by enterochromaffin-like (ECL) cells, at the histamine H2-receptors on parietal cells in the stomach, thereby inhibiting the normal and meal-stimulated secretion of stomach acid. In addition, other substances that promote acid secretion have a reduced effect on parietal cells when the H2 receptors are blocked.

FDA_UNII_Code

884KT10YB7

FULL_SYN

N-[2-[[[5-[(Dimethylamino)methyl]-2-furanyl]methyl]thio]ethyl]-N'-methyl-2-nitro-1,1-ethenediamine

RANITIDINE

Ranitidine

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C66505

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C66506

label

Ranitidine

Legacy Concept Name

Ranitidine

Preferred_Name

Ranitidine

prefixIRI

Thesaurus:C29412

Semantic_Type

Organic Chemical

Pharmacologic Substance

UMLS_CUI

C0034665

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29702

Delete Subject Author Type Created
No notes to display
Create mapping

Delete Mapping To Ontology Source
http://purl.obolibrary.org/obo/CHEBI_8776 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_8776 DOID LOOM
http://purl.obolibrary.org/obo/CHEBI_8776 CHEBI LOOM
http://www.co-ode.org/ontologies/galen#Ranitidine GALEN LOOM
http://purl.obolibrary.org/obo/OMIT_0012829 OMIT LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148012 NDFRT LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/372755005 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/ATC/A02BA02 ATC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D011899 RH-MESH LOOM
http://purl.obolibrary.org/obo/CHEBI_8776 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_8776 EUPATH LOOM
http://purl.obolibrary.org/obo/CHEBI_8776 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_8776 OBIB LOOM
http://purl.obolibrary.org/obo/CHEBI_8776 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_8776 HHEAR LOOM
http://purl.obolibrary.org/obo/CHEBI_8776 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_8776 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_8776 NIFSTD LOOM
http://purl.obolibrary.org/obo/MESH_D011899 BERO LOOM
http://purl.bioontology.org/ontology/RCD/x019Q RCD LOOM
http://purl.bioontology.org/ontology/CSP/4000-0309 CRISP LOOM
http://purl.obolibrary.org/obo/NCIT_C29412 BERO LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#10569 OCHV LOOM
https://go.drugbank.com/drugs/DB00863 MDM LOOM
http://purl.bioontology.org/ontology/RXNORM/9143 RXNORM LOOM
http://purl.bioontology.org/ontology/VANDF/4019927 VANDF LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.383.312.750 RH-MESH LOOM
http://purl.bioontology.org/ontology/MESH/D011899 MESH LOOM
http://stirdf.jst.go.jp/id/200907019426360449 IOBC LOOM
http://purl.jp/bio/4/id/200906069497356659 IOBC LOOM
http://www.drugbank.ca/drugs/DB00863 FTC LOOM
http://purl.bioontology.org/ontology/LNC/MTHU060474 LOINC LOOM
http://purl.bioontology.org/ontology/LNC/LP17253-3 LOINC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0034665 OCHV LOOM
http://www.phoc.org.cn/pmo/class/PMO_00018254 PMAPP-PMO LOOM
http://purl.bioontology.org/ontology/SNMI/C-84060 SNMI LOOM