loading...| Preferred Name |
Ramipril |
| Synonyms |
Altace Ramipril RAMIPRIL |
| Definitions |
A prodrug and nonsulfhydryl angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Ramipril is converted in the liver by de-esterification into its active form ramiprilat, which inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This abolishes the potent vasoconstrictive actions of angiotensin II and leads to vasodilatation. This agent also causes an increase in bradykinin levels and a decrease in angiotensin II-induced aldosterone secretion by the adrenal cortex, thereby promoting diuresis and natriuresis. |
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29411 |
| CAS_Registry |
87333-19-5 |
| CHEBI_ID |
CHEBI:8774 |
| Chemical_Formula |
C23H32N2O5 |
| code |
C29411 |
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977 |
| Contributing_Source |
CTRP FDA |
| DEFINITION |
A prodrug and nonsulfhydryl angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Ramipril is converted in the liver by de-esterification into its active form ramiprilat, which inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This abolishes the potent vasoconstrictive actions of angiotensin II and leads to vasodilatation. This agent also causes an increase in bradykinin levels and a decrease in angiotensin II-induced aldosterone secretion by the adrenal cortex, thereby promoting diuresis and natriuresis. |
| Display_Name |
Ramipril |
| FDA_UNII_Code |
L35JN3I7SJ |
| FULL_SYN |
Altace Ramipril RAMIPRIL |
| label |
Ramipril |
| Legacy_Concept_Name |
Ramipril |
| PDQ_Closed_Trial_Search_ID |
686948 |
| PDQ_Open_Trial_Search_ID |
686948 |
| Preferred_Name |
Ramipril |
| prefixIRI |
ncit:C29411 |
| Semantic_Type |
Pharmacologic Substance Organic Chemical |
| UMLS_CUI |
C0072973 |
| subClassOf |