National Cancer Institute Thesaurus

Last uploaded: November 25, 2019
Preferred Name

Ramipril

Synonyms

Altace

Ramipril

RAMIPRIL

Definitions

A prodrug and nonsulfhydryl angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Ramipril is converted in the liver by de-esterification into its active form ramiprilat, which inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This abolishes the potent vasoconstrictive actions of angiotensin II and leads to vasodilatation. This agent also causes an increase in bradykinin levels and a decrease in angiotensin II-induced aldosterone secretion by the adrenal cortex, thereby promoting diuresis and natriuresis.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29411

CAS_Registry

87333-19-5

CHEBI_ID

CHEBI:8774

Chemical_Formula

C23H32N2O5

code

C29411

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

Contributing_Source

CTRP

FDA

DEFINITION

A prodrug and nonsulfhydryl angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Ramipril is converted in the liver by de-esterification into its active form ramiprilat, which inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This abolishes the potent vasoconstrictive actions of angiotensin II and leads to vasodilatation. This agent also causes an increase in bradykinin levels and a decrease in angiotensin II-induced aldosterone secretion by the adrenal cortex, thereby promoting diuresis and natriuresis.

Display_Name

Ramipril

FDA_UNII_Code

L35JN3I7SJ

FULL_SYN

Altace

Ramipril

RAMIPRIL

label

Ramipril

Legacy_Concept_Name

Ramipril

PDQ_Closed_Trial_Search_ID

686948

PDQ_Open_Trial_Search_ID

686948

Preferred_Name

Ramipril

prefixIRI

ncit:C29411

Semantic_Type

Pharmacologic Substance

Organic Chemical

UMLS_CUI

C0072973

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C247

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http://purl.bioontology.org/ontology/PDQ/CDR0000686948 PDQ LOOM
http://purl.jp/bio/4/id/200906061080094006 IOBC LOOM
http://stirdf.jst.go.jp/id/200907036327252679 IOBC LOOM
http://mimi.case.edu/ontologies/2009/9/DrugOntology#ramipril SDO LOOM
http://purl.bioontology.org/ontology/MESH/D017257 MESH LOOM
http://purl.bioontology.org/ontology/UATC/C09AA05 ATC LOOM
http://purl.obolibrary.org/obo/CHEBI_8774 ODNAE LOOM
http://purl.obolibrary.org/obo/CHEBI_8774 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_8774 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_8774 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_8774 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_8774 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_8774 NIFSTD LOOM
https://bioportal.bioontology.org/ontologies/FTDM.owl#ramipril FASTO LOOM
http://purl.bioontology.org/ontology/LNC/LP171634-1 LOINC LOOM
http://purl.obolibrary.org/obo/XCO_0000548 XCO LOOM
http://purl.obolibrary.org/obo/XCO_0000548 XCO LOOM
http://purl.obolibrary.org/obo/XCO_0000548 XCO LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0072973 OCHV LOOM
http://www.drugbank.ca/drugs/DB00178 FTC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#14736 OCHV LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/386872004 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/VANDF/4019562 VANDF LOOM
http://bmi.utah.edu/ontologies/hfontology/C0072973 HFO LOOM
http://purl.bioontology.org/ontology/RXNORM/35296 NLMVS LOOM
http://purl.bioontology.org/ontology/RXNORM/35296 RXNORM LOOM
http://www.semanticweb.org/ontologies/STO.owl#f755b006_ddd3_4b8a_a155_5e3d704d69be CVAO LOOM
http://www.semanticweb.org/ontologies/STO.owl#f755b006_ddd3_4b8a_a155_5e3d704d69be STO-DRAFT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.605.084.750 RH-MESH LOOM
http://scai.fraunhofer.de/AlzheimerOntology#ramipril ADO LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000147662 ODAE LOOM
http://purl.bioontology.org/ontology/NDDF/003585 NDDF LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D017257 RH-MESH LOOM
http://purl.bioontology.org/ontology/RCD/bi6.. RCD LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147662 NDFRT LOOM
http://www.co-ode.org/ontologies/galen#Ramipril GALEN LOOM