Preferred Name |
Quinine Sulfate |
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Synonyms |
QUININE SULFATE Cinchonan-9-ol, 6'-methoxy-, (8 alpha,9R)-, Sulfate, Hydrate (2:1:2) Chininum Sulphuricum Quinine Sulfate Qualaquin |
|
Definitions |
The sulfate salt form of the quinidine alkaloid isolate quinine. Quinine has many mechanisms of action, including reduction of oxygen intake and carbohydrate metabolism; disruption of DNA replication and transcription via DNA intercalation; and reduction of the excitability of muscle fibers via alteration of calcium distribution. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (NCI04) |
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ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29399 |
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CAS_Registry |
207671-44-1 |
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CHEBI_ID |
CHEBI:52250 |
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Chemical_Formula |
2C20H24N2O2.2H2O.H2SO4 |
|
code |
C29399 |
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Concept_In_Subset | ||
Contributing_Source |
FDA |
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DEFINITION |
The sulfate salt form of the quinidine alkaloid isolate quinine. Quinine has many mechanisms of action, including reduction of oxygen intake and carbohydrate metabolism; disruption of DNA replication and transcription via DNA intercalation; and reduction of the excitability of muscle fibers via alteration of calcium distribution. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (NCI04) |
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FDA_UNII_Code |
KF7Z0E0Q2B |
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FULL_SYN |
QUININE SULFATE Cinchonan-9-ol, 6'-methoxy-, (8 alpha,9R)-, Sulfate, Hydrate (2:1:2) Chininum Sulphuricum Quinine Sulfate Qualaquin |
|
Has_Free_Acid_Or_Base_Form | ||
label |
Quinine Sulfate |
|
Legacy Concept Name |
Quinine_Sulfate |
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NSC Number |
5362 667852 |
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Preferred_Name |
Quinine Sulfate |
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prefixIRI |
Thesaurus:C29399 |
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Semantic_Type |
Organic Chemical Pharmacologic Substance |
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UMLS_CUI |
C0034422 |
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subClassOf |