National Cancer Institute Thesaurus

Last uploaded: October 28, 2019
Preferred Name

Pravastatin Sodium

Synonyms

Pravastatin Sodium

PRAVASTATIN SODIUM

pravastatin sodium

Definitions

The sodium salt of pravastatin with cholesterol-lowering and potential antineoplastic activities. Pravastatin competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. This agent lowers plasma cholesterol and lipoprotein levels, and modulates immune responses by suppressing MHC II (major histocompatibility complex II) on interferon gamma-stimulated, antigen-presenting cells such as human vascular endothelial cells. In addition, pravastatin, like other statins, exhibits pro-apoptotic, growth inhibitory, and pro-differentiation activities in a variety of tumor cells; these antineoplastic activities may be due, in part, to inhibition of the isoprenylation of Ras and Rho GTPases and related signaling cascades.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29375

ALT_DEFINITION

A drug used to lower the amount of cholesterol in the blood and to prevent stroke and heart attack. It is also being studied in the treatment of cancer and other conditions. Pravastatin sodium blocks an enzyme that helps make cholesterol in the body. It may also make tumor cells more sensitive to anticancer drugs. It is a type of HMG-CoA reductase inhibitor, a type of statin, and a type of chemosensitizer.

CAS_Registry

81131-70-6

CHEBI_ID

CHEBI:8361

Chemical_Formula

C23H35O7.Na

code

C29375

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

Contributing_Source

CTRP

FDA

DEFINITION

The sodium salt of pravastatin with cholesterol-lowering and potential antineoplastic activities. Pravastatin competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. This agent lowers plasma cholesterol and lipoprotein levels, and modulates immune responses by suppressing MHC II (major histocompatibility complex II) on interferon gamma-stimulated, antigen-presenting cells such as human vascular endothelial cells. In addition, pravastatin, like other statins, exhibits pro-apoptotic, growth inhibitory, and pro-differentiation activities in a variety of tumor cells; these antineoplastic activities may be due, in part, to inhibition of the isoprenylation of Ras and Rho GTPases and related signaling cascades.

Display_Name

Pravastatin Sodium

FDA_UNII_Code

3M8608UQ61

FULL_SYN

Pravastatin Sodium

PRAVASTATIN SODIUM

pravastatin sodium

Has_Free_Acid_Or_Base_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C62070

label

Pravastatin Sodium

Legacy_Concept_Name

Pravastatin

PDQ_Closed_Trial_Search_ID

424450

PDQ_Open_Trial_Search_ID

424450

Preferred_Name

Pravastatin Sodium

prefixIRI

ncit:C29375

Semantic_Type

Pharmacologic Substance

Organic Chemical

UMLS_CUI

C0700474

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1655

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http://purl.bioontology.org/ontology/RXNORM/203144 RXNORM LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/96306007 SNOMEDCT LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0700474 OCHV LOOM
http://purl.obolibrary.org/obo/CHEBI_8361 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_8361 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_8361 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_8361 CHEBI LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148190 NDFRT LOOM
http://purl.bioontology.org/ontology/VANDF/4020369 VANDF LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000148190 OCVDAE LOOM
http://www.co-ode.org/ontologies/galen#PravastatinSodium GALEN LOOM
http://stirdf.jst.go.jp/id/200907011445726364 IOBC LOOM
http://purl.jp/bio/4/id/200906050743253101 IOBC LOOM
http://purl.bioontology.org/ontology/SNMI/C-80821 SNMI LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000424450 PDQ LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0004006 DDO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0004006 DMTO LOOM
http://purl.bioontology.org/ontology/NDDF/003607 NDDF LOOM