National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Mirtazapine

Synonyms

MIRTAZAPINE

mirtazapine

Mirtazapine

Remeron

Definitions

A synthetic tetracyclic derivative of the piperazino-azepines with antidepressant activity. Although its mechanism of action is unknown, mirtazapine enhances central adrenergic and serotonergic transmission, possibly by acting as an antagonist at central presynaptic alpha 2 adrenergic inhibitory autoreceptors and heteroreceptors. This agent is a potent antagonist of 5-hydroxytryptamine type 2 (5-HT2), 5-HT3, and histamine 1 (H1) receptors, and a moderate antagonist of peripheral alpha 1 adrenergic and muscarinic receptors.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29265

ALT_DEFINITION

A drug used to treat depression. It belongs to the family of drugs called antidepressant agents.

CAS_Registry

61337-67-5

85650-52-8

CHEBI_ID

CHEBI:6950

Chemical_Formula

C17H19N3

code

C29265

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

CTRP

FDA

DEFINITION

A synthetic tetracyclic derivative of the piperazino-azepines with antidepressant activity. Although its mechanism of action is unknown, mirtazapine enhances central adrenergic and serotonergic transmission, possibly by acting as an antagonist at central presynaptic alpha 2 adrenergic inhibitory autoreceptors and heteroreceptors. This agent is a potent antagonist of 5-hydroxytryptamine type 2 (5-HT2), 5-HT3, and histamine 1 (H1) receptors, and a moderate antagonist of peripheral alpha 1 adrenergic and muscarinic receptors.

Display_Name

Mirtazapine

FDA_UNII_Code

A051Q2099Q

FULL_SYN

MIRTAZAPINE

mirtazapine

Mirtazapine

Remeron

label

Mirtazapine

Legacy Concept Name

Mirtazapine

NCI_Drug_Dictionary_ID

559298

PDQ_Closed_Trial_Search_ID

559298

PDQ_Open_Trial_Search_ID

559298

Preferred_Name

Mirtazapine

prefixIRI

Thesaurus:C29265

Semantic_Type

Organic Chemical

Pharmacologic Substance

UMLS_CUI

C0049506

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C265

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Delete Mapping To Ontology Source
http://www.case.edu/EpilepsyOntology.owl#Mirtazapine EPSO LOOM
https://bioportal.bioontology.org/ontologies/STMSO#Mirtazapine STMSO LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148449 NDFRT LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0049506 OCHV LOOM
http://www.drugbank.ca/drugs/DB00370 FTC LOOM
http://purl.bioontology.org/ontology/MESH/D000078785 MESH LOOM
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClass374ae25c_1fe3_4c1a_bf63_12a518dd4f8d WWECA LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000559298 PDQ LOOM
http://purl.bioontology.org/ontology/RCD/daB.. RCD LOOM
http://purl.jp/bio/4/id/200906032503840605 IOBC LOOM
http://purl.bioontology.org/ontology/LNC/LP19150-9 LOINC LOOM
http://www.case.edu/EpSO.owl#Mirtazapine MEPO LOOM
http://www.phoc.org.cn/pmo/class/PMO_00026446 PMAPP-PMO LOOM
http://purl.bioontology.org/ontology/ATC/N06AX11 ATC LOOM
http://purl.bioontology.org/ontology/LNC/MTHU007402 LOINC LOOM
http://scai.fraunhofer.de/AlzheimerOntology#mirtazapine ADO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C035133 RH-MESH LOOM
http://www.co-ode.org/ontologies/galen#Mirtazapine GALEN LOOM
http://doe-generated-ontology.com/OntoAD#C0049506 ONTOAD LOOM
http://purl.bioontology.org/ontology/RXNORM/15996 RXNORM LOOM
http://purl.obolibrary.org/obo/CHEBI_6950 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_6950 FIDEO LOOM
http://purl.obolibrary.org/obo/CHEBI_6950 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_6950 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_6950 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_6950 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_6950 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_6950 NIFSTD LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#13392 OCHV LOOM
http://purl.bioontology.org/ontology/NDDF/006054 NDDF LOOM
http://stirdf.jst.go.jp/id/200907007216164428 IOBC LOOM
http://purl.obolibrary.org/obo/NCIT_C29265 BERO LOOM
https://go.drugbank.com/drugs/DB00370 MDM LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/386847004 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/VANDF/4020978 VANDF LOOM