Preferred Name |
Mirtazapine |
|
Synonyms |
MIRTAZAPINE mirtazapine Mirtazapine Remeron |
|
Definitions |
A synthetic tetracyclic derivative of the piperazino-azepines with antidepressant activity. Although its mechanism of action is unknown, mirtazapine enhances central adrenergic and serotonergic transmission, possibly by acting as an antagonist at central presynaptic alpha 2 adrenergic inhibitory autoreceptors and heteroreceptors. This agent is a potent antagonist of 5-hydroxytryptamine type 2 (5-HT2), 5-HT3, and histamine 1 (H1) receptors, and a moderate antagonist of peripheral alpha 1 adrenergic and muscarinic receptors. |
|
ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29265 |
|
ALT_DEFINITION |
A drug used to treat depression. It belongs to the family of drugs called antidepressant agents. |
|
CAS_Registry |
61337-67-5 85650-52-8 |
|
CHEBI_ID |
CHEBI:6950 |
|
Chemical_Formula |
C17H19N3 |
|
code |
C29265 |
|
Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
|
Contributing_Source |
CTRP FDA |
|
DEFINITION |
A synthetic tetracyclic derivative of the piperazino-azepines with antidepressant activity. Although its mechanism of action is unknown, mirtazapine enhances central adrenergic and serotonergic transmission, possibly by acting as an antagonist at central presynaptic alpha 2 adrenergic inhibitory autoreceptors and heteroreceptors. This agent is a potent antagonist of 5-hydroxytryptamine type 2 (5-HT2), 5-HT3, and histamine 1 (H1) receptors, and a moderate antagonist of peripheral alpha 1 adrenergic and muscarinic receptors. |
|
Display_Name |
Mirtazapine |
|
FDA_UNII_Code |
A051Q2099Q |
|
FULL_SYN |
MIRTAZAPINE mirtazapine Mirtazapine Remeron |
|
label |
Mirtazapine |
|
Legacy Concept Name |
Mirtazapine |
|
NCI_Drug_Dictionary_ID |
559298 |
|
PDQ_Closed_Trial_Search_ID |
559298 |
|
PDQ_Open_Trial_Search_ID |
559298 |
|
Preferred_Name |
Mirtazapine |
|
prefixIRI |
Thesaurus:C29265 |
|
Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
UMLS_CUI |
C0049506 |
|
subClassOf |