National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Lansoprazole

Synonyms

Lansoprazole

LANSOPRAZOLE

Prevacid

Definitions

A substituted benzimidazole prodrug with selective and irreversible proton pump inhibitor activity. Lansoprazole prodrug is converted to an active sulfonamide derivative in the acidic environment of the gastric parietal cell; the sulfonamide derivative binds to the gastric proton pump H+/K+ ATPase and forms a stable disulfide bond with the sulfhydryl group near the potassium-binding site on the luminal side, resulting in inactivation of the ATPase and a reduction in gastric acid secretion. This agent does not have anticholinergic or histamine H2 -receptor antagonistic properties.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29150

CAS_Registry

103577-45-3

CHEBI_ID

CHEBI:6375

Chemical_Formula

C16H14F3N3O2S

code

C29150

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

HemOnc

DEFINITION

A substituted benzimidazole prodrug with selective and irreversible proton pump inhibitor activity. Lansoprazole prodrug is converted to an active sulfonamide derivative in the acidic environment of the gastric parietal cell; the sulfonamide derivative binds to the gastric proton pump H+/K+ ATPase and forms a stable disulfide bond with the sulfhydryl group near the potassium-binding site on the luminal side, resulting in inactivation of the ATPase and a reduction in gastric acid secretion. This agent does not have anticholinergic or histamine H2 -receptor antagonistic properties.

FDA_UNII_Code

0K5C5T2QPG

FULL_SYN

Lansoprazole

LANSOPRAZOLE

Prevacid

label

Lansoprazole

Legacy Concept Name

Lansoprazole

NCI_Drug_Dictionary_ID

483101

PDQ_Closed_Trial_Search_ID

483101

PDQ_Open_Trial_Search_ID

483101

Preferred_Name

Lansoprazole

prefixIRI

Thesaurus:C29150

Semantic_Type

Organic Chemical

Pharmacologic Substance

UMLS_CUI

C0050940

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29723

Delete Subject Author Type Created
No notes to display
Create mapping

Delete Mapping To Ontology Source
http://stirdf.jst.go.jp/id/200907064566418205 IOBC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0050940 OCHV LOOM
http://purl.jp/bio/4/id/200906089294023299 IOBC LOOM
http://purl.bioontology.org/ontology/NDDF/004456 NDDF LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.886.640.074.249 RH-MESH LOOM
http://www.drugbank.ca/drugs/DB00448 FTC LOOM
http://purl.bioontology.org/ontology/VANDF/4020922 VANDF LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#13435 OCHV LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.383.725.024.249 RH-MESH LOOM
https://go.drugbank.com/drugs/DB00448 MDM LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.438.103.034.249 RH-MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D064747 RH-MESH LOOM
http://purl.obolibrary.org/obo/CHEBI_6375 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_6375 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_6375 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_6375 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_6375 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_6375 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_6375 NIFSTD LOOM
http://purl.obolibrary.org/obo/CHEBI_6375 ODNAE LOOM
http://purl.obolibrary.org/obo/NCIT_C29150 BERO LOOM
http://purl.obolibrary.org/obo/OMIT_0028518 OMIT LOOM
http://www.co-ode.org/ontologies/galen#Lansoprazole GALEN LOOM
http://www.phoc.org.cn/pmo/class/PMO_00017447 PMAPP-PMO LOOM
http://purl.bioontology.org/ontology/MESH/D064747 MESH LOOM
http://purl.bioontology.org/ontology/ATC/A02BC03 ATC LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000148407 ODAE LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/386888004 SNOMEDCT LOOM
http://purl.obolibrary.org/obo/MESH_D064747 BERO LOOM
http://purl.bioontology.org/ontology/RCD/a6c.. RCD LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148407 NDFRT LOOM
http://purl.bioontology.org/ontology/LNC/LP171614-3 LOINC LOOM
http://purl.bioontology.org/ontology/RXNORM/17128 RXNORM LOOM