National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
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Preferred Name

Insulin, Regular
Synonyms

Insulin, Regular

Humulin R

Novolin R
Definitions

A recombinant form of the naturally occurring human pancreatic hormone insulin. Upon administration, regular insulin mimics the action of endogenous human insulin and binds to insulin receptors located on muscle and fat cells. This both facilitates the cellular uptake of glucose and lowers blood glucose levels. In addition, insulin inhibits the liver's conversion of stored glycogen into glucose, which also decreases blood glucose levels. Insulin also inhibits lipolysis in adipose tissue, inhibits proteolysis, and enhances protein synthesis.
ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29125
code

C29125
Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424
DEFINITION

A recombinant form of the naturally occurring human pancreatic hormone insulin. Upon administration, regular insulin mimics the action of endogenous human insulin and binds to insulin receptors located on muscle and fat cells. This both facilitates the cellular uptake of glucose and lowers blood glucose levels. In addition, insulin inhibits the liver's conversion of stored glycogen into glucose, which also decreases blood glucose levels. Insulin also inhibits lipolysis in adipose tissue, inhibits proteolysis, and enhances protein synthesis.
FULL_SYN

Insulin, Regular

Humulin R

Novolin R
label

Insulin, Regular
Legacy Concept Name

Regular_Insulin
NCI_Drug_Dictionary_ID

764093
PDQ_Closed_Trial_Search_ID

764093
PDQ_Open_Trial_Search_ID

764093
Preferred_Name

Insulin, Regular
prefixIRI

Thesaurus:C29125
Semantic_Type

Amino Acid, Peptide, or Protein

Pharmacologic Substance
UMLS_CUI

C0021641
subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C581
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