loading...| Preferred Name |
Gemfibrozil |
|
| Synonyms |
GEMFIBROZIL Gemfibrozil Lopid |
|
| Definitions |
A fibric acid derivative with hypolipidemic effects. Gemfibrozil interacts with peroxisome proliferator-activated receptors (PPARalpha) resulting in PPARalpha-mediated stimulation of fatty acid oxidation and an increase in lipoprotein lipase (LPL) synthesis. This enhances triglyceride-rich lipoprotein clearance and reduces the expression of apolipoprotein C-III (apoC-III). The reduction in hepatic production of apoC-III results in subsequent reduction of serum levels of very-low-density-lipoprotein cholesterol (VLDL-C). In addition, gemfibrozil-mediated PPARalpha stimulation of apoA-I and apoA-II expression results in an increase in high-density lipoprotein cholesterol (HDL-C). |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29071 |
|
| CAS_Registry |
25812-30-0 |
|
| CHEBI_ID |
CHEBI:5296 |
|
| Chemical_Formula |
C15H22O3 |
|
| code |
C29071 |
|
| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
|
| Contributing_Source |
CTRP FDA |
|
| DEFINITION |
A fibric acid derivative with hypolipidemic effects. Gemfibrozil interacts with peroxisome proliferator-activated receptors (PPARalpha) resulting in PPARalpha-mediated stimulation of fatty acid oxidation and an increase in lipoprotein lipase (LPL) synthesis. This enhances triglyceride-rich lipoprotein clearance and reduces the expression of apolipoprotein C-III (apoC-III). The reduction in hepatic production of apoC-III results in subsequent reduction of serum levels of very-low-density-lipoprotein cholesterol (VLDL-C). In addition, gemfibrozil-mediated PPARalpha stimulation of apoA-I and apoA-II expression results in an increase in high-density lipoprotein cholesterol (HDL-C). |
|
| Display_Name |
Gemfibrozil |
|
| FDA_UNII_Code |
Q8X02027X3 |
|
| FULL_SYN |
GEMFIBROZIL Gemfibrozil Lopid |
|
| label |
Gemfibrozil |
|
| Legacy Concept Name |
Gemfibrozil |
|
| NCI_Drug_Dictionary_ID |
715911 |
|
| PDQ_Closed_Trial_Search_ID |
715911 |
|
| PDQ_Open_Trial_Search_ID |
715911 |
|
| Preferred_Name |
Gemfibrozil |
|
| prefixIRI |
Thesaurus:C29071 |
|
| Semantic_Type |
Pharmacologic Substance |
|
| UMLS_CUI |
C0017245 |
|
| subClassOf |