National Cancer Institute Thesaurus

Last uploaded: May 28, 2019
Preferred Name

Gemfibrozil

Synonyms

GEMFIBROZIL

Gemfibrozil

Lopid

Definitions

A fibric acid derivative with hypolipidemic effects. Gemfibrozil interacts with peroxisome proliferator-activated receptors (PPARalpha) resulting in PPARalpha-mediated stimulation of fatty acid oxidation and an increase in lipoprotein lipase (LPL) synthesis. This enhances triglyceride-rich lipoprotein clearance and reduces the expression of apolipoprotein C-III (apoC-III). The reduction in hepatic production of apoC-III results in subsequent reduction of serum levels of very-low-density-lipoprotein cholesterol (VLDL-C). In addition, gemfibrozil-mediated PPARalpha stimulation of apoA-I and apoA-II expression results in an increase in high-density lipoprotein cholesterol (HDL-C).

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29071

CAS_Registry

25812-30-0

CHEBI_ID

CHEBI:5296

Chemical_Formula

C15H22O3

code

C29071

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

Contributing_Source

CTRP

FDA

DEFINITION

A fibric acid derivative with hypolipidemic effects. Gemfibrozil interacts with peroxisome proliferator-activated receptors (PPARalpha) resulting in PPARalpha-mediated stimulation of fatty acid oxidation and an increase in lipoprotein lipase (LPL) synthesis. This enhances triglyceride-rich lipoprotein clearance and reduces the expression of apolipoprotein C-III (apoC-III). The reduction in hepatic production of apoC-III results in subsequent reduction of serum levels of very-low-density-lipoprotein cholesterol (VLDL-C). In addition, gemfibrozil-mediated PPARalpha stimulation of apoA-I and apoA-II expression results in an increase in high-density lipoprotein cholesterol (HDL-C).

Display_Name

Gemfibrozil

FDA_UNII_Code

Q8X02027X3

FULL_SYN

GEMFIBROZIL

Gemfibrozil

Lopid

label

Gemfibrozil

Legacy_Concept_Name

Gemfibrozil

PDQ_Closed_Trial_Search_ID

715911

PDQ_Open_Trial_Search_ID

715911

Preferred_Name

Gemfibrozil

prefixIRI

ncit:C29071

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0017245

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C98150

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http://purl.bioontology.org/ontology/CSP/5001-0016 CRISP LOOM
http://stirdf.jst.go.jp/id/200907081927122227 IOBC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.241.081.114.968.500.750 RH-MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D10.251.400.895.593.350 RH-MESH LOOM
http://purl.bioontology.org/ontology/RXNORM/4719 RXNORM LOOM
http://purl.bioontology.org/ontology/LNC/LP15168-5 LOINC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D015248 RH-MESH LOOM
http://www.drugbank.ca/drugs/DB01241 FTC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.355.726.305.750 RH-MESH LOOM
http://www.semanticweb.org/ontologies/STO.owl#e237d4_9d0d_4d99_b7ca_b43bbf5b5925 CVAO LOOM
http://www.semanticweb.org/ontologies/STO.owl#e237d4_9d0d_4d99_b7ca_b43bbf5b5925 STO-DRAFT LOOM
http://purl.bioontology.org/ontology/SNMI/C-80660 SNMI LOOM
http://www.co-ode.org/ontologies/galen#Gemfibrozil GALEN LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.241.081.944.509.350 RH-MESH LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387189002 SNOMEDCT LOOM
http://purl.jp/bio/4/id/200906031161703582 IOBC LOOM
http://purl.obolibrary.org/obo/CHEBI_5296 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_5296 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_5296 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_5296 CCONT LOOM
http://purl.obolibrary.org/obo/CHEBI_5296 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_5296 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_5296 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_5296 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_5296 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_5296 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_5296 NIFSTD LOOM
http://purl.bioontology.org/ontology/MESH/D015248 MESH LOOM
http://purl.bioontology.org/ontology/VANDF/4018639 VANDF LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146952 NDFRT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.455.426.559.389.657.654.305.750 RH-MESH LOOM
http://purl.bioontology.org/ontology/UATC/C10AB04 ATC LOOM
http://purl.bioontology.org/ontology/LNC/MTHU002557 LOINC LOOM