National Cancer Institute Thesaurus

Last uploaded: February 4, 2019
Preferred Name

Felodipine

Synonyms

Felodipine

FELODIPINE

Plendil

Definitions

A dihydropyridine calcium channel blocking agent. Felodipine inhibits the influx of extracellular calcium ions into myocardial and vascular smooth muscle cells, causing dilatation of the main coronary and systemic arteries and decreasing myocardial contractility. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in some multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (NCI04)

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29046

CAS_Registry

72509-76-3

CHEBI_ID

CHEBI:585948

Chemical_Formula

C18H19Cl2NO4

code

C29046

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A dihydropyridine calcium channel blocking agent. Felodipine inhibits the influx of extracellular calcium ions into myocardial and vascular smooth muscle cells, causing dilatation of the main coronary and systemic arteries and decreasing myocardial contractility. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in some multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (NCI04)

FDA_UNII_Code

OL961R6O2C

FULL_SYN

Felodipine

FELODIPINE

Plendil

label

Felodipine

Legacy_Concept_Name

Felodipine

Preferred_Name

Felodipine

prefixIRI

ncit:C29046

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0015772

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C333

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http://purl.bioontology.org/ontology/NDFRT/N0000148116 NDFRT LOOM
http://www.co-ode.org/ontologies/galen#Felodipine GALEN LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/386863007 SNOMEDCT LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000148116 OCVDAE LOOM
http://purl.bioontology.org/ontology/UATC/C08CA02 ATC LOOM
http://purl.obolibrary.org/obo/CHEBI_585948 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_585948 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_585948 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_585948 CCONT LOOM
http://purl.obolibrary.org/obo/CHEBI_585948 NBO LOOM
http://purl.obolibrary.org/obo/CHEBI_585948 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_585948 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_585948 DRON LOOM
http://www.drugbank.ca/drugs/DB01023 FTC LOOM
http://purl.bioontology.org/ontology/NDDF/003602 NDDF LOOM
http://purl.bioontology.org/ontology/VANDF/4020159 VANDF LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/108535009 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/RCD/blc.. RCD LOOM
http://purl.bioontology.org/ontology/RXNORM/4316 RXNORM LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.383.725.203.250 RH-MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D015736 RH-MESH LOOM
http://bmi.utah.edu/ontologies/hfontology/C0015772 HFO LOOM
http://purl.jp/bio/4/id/200906048500995334 IOBC LOOM
http://mimi.case.edu/ontologies/2009/9/DrugOntology#felodipine SDO LOOM
http://purl.bioontology.org/ontology/MESH/D015736 MESH LOOM