National Cancer Institute Thesaurus

Last uploaded: December 30, 2019
Preferred Name

Doxycycline Hyclate

Synonyms

DOXYCYCLINE HYCLATE

Doryx

Doxycycline Hyclate

doxycycline hyclate

Definitions

The hyclate salt form of doxycycline, a synthetic, broad-spectrum tetracycline antibiotic exhibiting antimicrobial activity. Doxycycline hyclate binds reversibly to the 30S ribosomal subunit, possibly to the 50S ribosomal subunit as well, thereby blocking the binding of aminoacyl-tRNA to the mRNA-ribosome complex. This leads to an inhibition of protein synthesis. In addition, this agent has exhibited inhibition of collagenase activity.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29007

ALT_DEFINITION

A drug used to treat many types of bacterial infections. It stops the growth of bacteria by keeping them from making proteins. It is a type of antibiotic.

CAS_Registry

24390-14-5

CHEBI_ID

CHEBI:34730

Chemical_Formula

2C22H24N2O8.C2H6O.2HCl.H2O

code

C29007

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

Contributing_Source

CTRP

FDA

DEFINITION

The hyclate salt form of doxycycline, a synthetic, broad-spectrum tetracycline antibiotic exhibiting antimicrobial activity. Doxycycline hyclate binds reversibly to the 30S ribosomal subunit, possibly to the 50S ribosomal subunit as well, thereby blocking the binding of aminoacyl-tRNA to the mRNA-ribosome complex. This leads to an inhibition of protein synthesis. In addition, this agent has exhibited inhibition of collagenase activity.

Display_Name

Doxycycline Hyclate

FDA_UNII_Code

19XTS3T51U

FULL_SYN

DOXYCYCLINE HYCLATE

Doryx

Doxycycline Hyclate

doxycycline hyclate

Has_Free_Acid_Or_Base_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C457

label

Doxycycline Hyclate

Legacy_Concept_Name

Doxycline_Hyclate

PDQ_Closed_Trial_Search_ID

669084

PDQ_Open_Trial_Search_ID

669084

Preferred_Name

Doxycycline Hyclate

prefixIRI

ncit:C29007

Semantic_Type

Organic Chemical

Antibiotic

UMLS_CUI

C0058731

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1595

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Delete Mapping To Ontology Source
http://purl.bioontology.org/ontology/VANDF/4017738 VANDF LOOM
http://purl.bioontology.org/ontology/SNMI/C-55022 SNMI LOOM
http://www.co-ode.org/ontologies/galen#DoxycyclineHyclate GALEN LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0058731 OCHV LOOM
http://purl.bioontology.org/ontology/NDDF/002750 NDDF LOOM
http://purl.obolibrary.org/obo/CHEBI_34730 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_34730 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_34730 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_34730 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_34730 CHEBI LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#13919 OCHV LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146105 NDFRT LOOM
http://purl.bioontology.org/ontology/RXNORM/23663 RXNORM LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/71417000 SNOMEDCT LOOM