National Cancer Institute Thesaurus

Last uploaded: June 25, 2019
Preferred Name

Digoxin

Synonyms

DIGOXIN

3beta,12beta,14-Trihydroxy-5beta,14beta-card-20(22)-enolid-3-tridigitoxosid

12beta-Hydroxydigitoxin

Cardiogoxin

digoxin

Lanoxin

Digoxin

Digoxigenin-tridigitoxosid

Definitions

A cardiac glycoside. Digoxin inhibits the sodium potassium adenosine triphosphatase (ATPase) pump, thereby increasing intracellular calcium and enhancing cardiac contractility. This agent also acts directly on the atrioventricular node to suppress conduction, thereby slowing conduction velocity. Apparently due to its effects on intracellular calcium concentrations, digoxin induces apoptosis of tumor cells via a pathway involving mitochondrial cytochrome c and caspases 8 and 3. (NCI04)

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28990

ALT_DEFINITION

A drug used to treat irregular heartbeat and some types of heart failure. It is also being studied in the treatment of some types of cancer. Digoxin helps the heart work normally by controlling the amount of calcium that goes into the heart muscle. It also may kill cancer cells and make them more sensitive to anticancer drugs. It is a type of cardiac glycoside.

CAS_Registry

20830-75-5

CHEBI_ID

CHEBI:4551

Chemical_Formula

C41H64O14

code

C28990

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

Contributing_Source

CTRP

FDA

DEFINITION

A cardiac glycoside. Digoxin inhibits the sodium potassium adenosine triphosphatase (ATPase) pump, thereby increasing intracellular calcium and enhancing cardiac contractility. This agent also acts directly on the atrioventricular node to suppress conduction, thereby slowing conduction velocity. Apparently due to its effects on intracellular calcium concentrations, digoxin induces apoptosis of tumor cells via a pathway involving mitochondrial cytochrome c and caspases 8 and 3. (NCI04)

Display_Name

Digoxin

FDA_UNII_Code

73K4184T59

FULL_SYN

DIGOXIN

3beta,12beta,14-Trihydroxy-5beta,14beta-card-20(22)-enolid-3-tridigitoxosid

12beta-Hydroxydigitoxin

Cardiogoxin

digoxin

Lanoxin

Digoxin

Digoxigenin-tridigitoxosid

label

Digoxin

Legacy_Concept_Name

Digoxin

NSC_Code

95100

PDQ_Closed_Trial_Search_ID

485249

PDQ_Open_Trial_Search_ID

485249

Preferred_Name

Digoxin

prefixIRI

ncit:C28990

Semantic_Type

Pharmacologic Substance

Organic Chemical

UMLS_CUI

C0012265

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C78322

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C823

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http://purl.bioontology.org/ontology/CPT/1022259 CPT LOOM
http://purl.obolibrary.org/obo/dinto_2861 DINTO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D04.808.155.160.349 RH-MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D004077 RH-MESH LOOM
http://purl.obolibrary.org/obo/CHEBI_4551 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_4551 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_4551 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_4551 MONDO LOOM
http://purl.obolibrary.org/obo/CHEBI_4551 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_4551 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_4551 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_4551 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_4551 HINO LOOM
http://bmi.utah.edu/ontologies/hfontology/C0012265 HFO LOOM
http://purl.bioontology.org/ontology/CSP/0567-2682 CRISP LOOM
http://purl.bioontology.org/ontology/RXNORM/3407 RXNORM LOOM
http://d-nb.info/gnd/4012306-6 FAST-TOPICAL LOOM
http://purl.bioontology.org/ontology/SNMI/C-80330 SNMI LOOM
http://purl.bioontology.org/ontology/VANDF/4018047 VANDF LOOM
http://purl.bioontology.org/ontology/UATC/C01AA05 ATC LOOM
http://purl.obolibrary.org/obo/XCO_0000619 XCO LOOM
http://purl.bioontology.org/ontology/NDDF/000593 NDDF LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000485249 PDQ LOOM
http://purl.bioontology.org/ontology/LNC/LP14714-7 LOINC LOOM
https://bioportal.bioontology.org/ontologies/DMTO.owl#DMTO_0001804 DMTO LOOM
http://ontology.apa.org/apaonto/termsonlyOUT%20(5).owl#Digoxin APAONTO LOOM
http://purl.bioontology.org/ontology/MESH/D004077 MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D04.808.155.580.130.500.436 RH-MESH LOOM
http://stirdf.jst.go.jp/id/200907085872788919 IOBC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D09.408.180.261.436 RH-MESH LOOM
https://bioportal.bioontology.org/ontologies/FTDM.owl#DMTO_0001804 FASTO LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146388 NDFRT LOOM
http://purl.jp/bio/4/id/200906050095521421 IOBC LOOM
http://www.drugbank.ca/drugs/DB00390 FTC LOOM
http://purl.bioontology.org/ontology/LNC/MTHU001808 LOINC LOOM
http://www.co-ode.org/ontologies/galen#Digoxin GALEN LOOM
http://id.loc.gov/authorities/subjects/sh85037995 FAST-TOPICAL LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387461009 SNOMEDCT LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000146388 OCVDAE LOOM