National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Adapalene

Synonyms

6-(3-(1-Adamantyl)-4-methoxyphenyl)-2-naphthoic acid

6-(4-Methoxy-3-tricyclo(3.3.1.13,7)dec-1-ylphenyl)-2-naphthalenecarboxylic Acid

ADAPALENE

Adapalene

CD271

Differin

Definitions

A topical retinoid-like compound, chemically similar to vitamin A. Although the exact mechanism of action is unknown, adapalene binds to specific retinoic acid receptors in the nucleus, leading to specific gene expression. This agent stimulates skin growth through modulation of cellular differentiation, inflammatory processes and keratinization of follicular epithelial cells. Adapalene may increase dermal sensitivity to ultraviolet radiation. (NCI04)

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28989

Accepted_Therapeutic_Use_For

Topical treatment of acne vulgaris

CAS_Registry

106685-40-9

CHEBI_ID

CHEBI:31174

Chemical_Formula

C28H28O3

code

C28989

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A topical retinoid-like compound, chemically similar to vitamin A. Although the exact mechanism of action is unknown, adapalene binds to specific retinoic acid receptors in the nucleus, leading to specific gene expression. This agent stimulates skin growth through modulation of cellular differentiation, inflammatory processes and keratinization of follicular epithelial cells. Adapalene may increase dermal sensitivity to ultraviolet radiation. (NCI04)

FDA_UNII_Code

1L4806J2QF

FULL_SYN

6-(3-(1-Adamantyl)-4-methoxyphenyl)-2-naphthoic acid

6-(4-Methoxy-3-tricyclo(3.3.1.13,7)dec-1-ylphenyl)-2-naphthalenecarboxylic Acid

ADAPALENE

Adapalene

CD271

Differin

label

Adapalene

Legacy Concept Name

Adapalene

NCI_Drug_Dictionary_ID

805120

Preferred_Name

Adapalene

prefixIRI

Thesaurus:C28989

Semantic_Type

Pharmacologic Substance

UMLS_CUI

C0165631

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C804

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Delete Mapping To Ontology Source
http://purl.bioontology.org/ontology/SNOMEDCT/386934008 SNOMEDCT LOOM
http://purl.jp/bio/4/id/200906076199760982 IOBC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0165631 OCHV LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148452 NDFRT LOOM
http://purl.bioontology.org/ontology/ATC/D10AD03 ATC LOOM
http://purl.obolibrary.org/obo/OMIT_0001331 OMIT LOOM
http://stirdf.jst.go.jp/id/200907009404272630 IOBC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C063610 RH-MESH LOOM
http://www.drugbank.ca/drugs/DB00210 FTC LOOM
http://purl.bioontology.org/ontology/VANDF/4020981 VANDF LOOM
http://www.co-ode.org/ontologies/galen#Adapalene GALEN LOOM
http://purl.bioontology.org/ontology/NDDF/005905 NDDF LOOM
http://purl.bioontology.org/ontology/RXNORM/60223 RXNORM LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#18073 OCHV LOOM
http://www.phoc.org.cn/pmo/class/PMO_00016937 PMAPP-PMO LOOM
http://purl.obolibrary.org/obo/NCIT_C28989 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_31174 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_31174 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_31174 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_31174 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_31174 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_31174 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_31174 NIFSTD LOOM
http://purl.obolibrary.org/obo/MESH_D000068816 BERO LOOM
https://go.drugbank.com/drugs/DB00210 MDM LOOM
http://purl.bioontology.org/ontology/RCD/m6D.. RCD LOOM
http://purl.bioontology.org/ontology/MESH/D000068816 MESH LOOM