National Cancer Institute Thesaurus

Last uploaded: May 28, 2019
Preferred Name

Diclofenac

Synonyms

Diclofenac

DICLOFENAC

diclofenac

2-[(2,6-Dichlorophenyl)amino]benzeneacetic Acid

Definitions

A nonsteroidal benzeneacetic acid derivative with anti-inflammatory activity. As a nonsteroidal anti-inflammatory drug (NSAID), diclofenac binds and chelates both isoforms of cyclooxygenase (COX-1 and-2), thereby blocking the conversion of arachidonic acid to pro-inflammatory-proprostaglandins. This agent also may inhibit COX-2-mediated tumor angiogenesis. When inhibiting COX-2, diclofenac may be effective in relieving pain and inflammation; when inhibiting COX-1, it may produce unacceptable gastrointestinal side effects. This agent may be more active against COX-2 than several other carboxylic acid-containing NSAIDs. (NCI04)

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28985

ALT_DEFINITION

The active ingredient in a drug that is used to treat the symptoms of rheumatoid arthritis and is being studied in the prevention and treatment of some types of skin cancer. It blocks substances that cause inflammation and pain. It may also prevent the growth of new blood vessels that tumors need to grow. It is a type of cyclooxygenase inhibitor, a type of nonsteroidal anti-inflammatory drug (NSAID), and a type of antiangiogenesis agent.

CAS_Registry

15307-86-5

CHEBI_ID

CHEBI:47381

Chemical_Formula

C14H11Cl2NO2

code

C28985

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A nonsteroidal benzeneacetic acid derivative with anti-inflammatory activity. As a nonsteroidal anti-inflammatory drug (NSAID), diclofenac binds and chelates both isoforms of cyclooxygenase (COX-1 and-2), thereby blocking the conversion of arachidonic acid to pro-inflammatory-proprostaglandins. This agent also may inhibit COX-2-mediated tumor angiogenesis. When inhibiting COX-2, diclofenac may be effective in relieving pain and inflammation; when inhibiting COX-1, it may produce unacceptable gastrointestinal side effects. This agent may be more active against COX-2 than several other carboxylic acid-containing NSAIDs. (NCI04)

FDA_UNII_Code

144O8QL0L1

FULL_SYN

Diclofenac

DICLOFENAC

diclofenac

2-[(2,6-Dichlorophenyl)amino]benzeneacetic Acid

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47984

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47983

label

Diclofenac

Legacy_Concept_Name

Diclofenac

Preferred_Name

Diclofenac

prefixIRI

ncit:C28985

Semantic_Type

Pharmacologic Substance

Organic Chemical

UMLS_CUI

C0012091

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1323

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http://www.drugbank.ca/drugs/DB00586 FTC LOOM
http://purl.bioontology.org/ontology/NDDF/004409 NDDF LOOM
http://purl.bioontology.org/ontology/RCD/x01Ky RCD LOOM
http://purl.bioontology.org/ontology/VANDF/4019714 VANDF LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.241.223.601.210 RH-MESH LOOM
http://purl.bioontology.org/ontology/UATC/D11AX18 ATC LOOM
http://d-nb.info/gnd/4239268-8 FAST-TOPICAL LOOM
http://purl.bioontology.org/ontology/UATC/M01AB05 ATC LOOM
http://purl.bioontology.org/ontology/MESH/D004008 MESH LOOM
http://scai.fraunhofer.de/AlzheimerOntology#diclofenac ADO LOOM
http://scdontology.h3abionet.org/ontology/SCDO_0000380 SCDO LOOM
http://stirdf.jst.go.jp/id/200907062105951731 IOBC LOOM
http://purl.bioontology.org/ontology/RXNORM/3355 RXNORM LOOM
http://www.co-ode.org/ontologies/galen#Diclofenac GALEN LOOM
http://purl.bioontology.org/ontology/LNC/MTHU024758 LOINC LOOM
http://purl.obolibrary.org/obo/CHEBI_47381 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_47381 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_47381 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_47381 CCONT LOOM
http://purl.obolibrary.org/obo/CHEBI_47381 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_47381 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_47381 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_47381 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_47381 DIDEO LOOM
http://purl.obolibrary.org/obo/CHEBI_47381 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_47381 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_47381 NIFSTD LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D004008 RH-MESH LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/7034005 SNOMEDCT LOOM
http://bmi.utah.edu/ontologies/peontology/C0012091 RAO LOOM
http://purl.jp/bio/4/id/200906068249155586 IOBC LOOM
http://purl.bioontology.org/ontology/UATC/M02AA15 ATC LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147806 NDFRT LOOM
http://purl.bioontology.org/ontology/UATC/S01BC03 ATC LOOM
http://purl.bioontology.org/ontology/LNC/LP17915-7 LOINC LOOM
http://purl.bioontology.org/ontology/SNMI/C-60390 SNMI LOOM