loading...| Preferred Name |
Lamivudine/Zidovudine |
|
| Synonyms |
Lamivudine/Zidovudine Combivir |
|
| Definitions |
A combination of two synthetic nucleoside analogues with synergistic antiviral properties. Lamivudine is phosphorylated intracellularly to its active 5'-triphosphate metabolite, lamivudine triphosphate (L-TP); zidovudine is phosphorylated to its active 5'-triphosphate metabolite, zidovudine triphosphate (ZDV-TP). These active metabolites inhibit human immunodeficiency virus (HIV) viral reverse transcriptase (RT) by incorporating into viral DNA and terminating viral DNA chain elongation. (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28939 |
|
| code |
C28939 |
|
| Concept_Status |
Obsolete_Concept |
|
| DEFINITION |
A combination of two synthetic nucleoside analogues with synergistic antiviral properties. Lamivudine is phosphorylated intracellularly to its active 5'-triphosphate metabolite, lamivudine triphosphate (L-TP); zidovudine is phosphorylated to its active 5'-triphosphate metabolite, zidovudine triphosphate (ZDV-TP). These active metabolites inhibit human immunodeficiency virus (HIV) viral reverse transcriptase (RT) by incorporating into viral DNA and terminating viral DNA chain elongation. (NCI04) |
|
| FULL_SYN |
Lamivudine/Zidovudine Combivir |
|
| label |
Lamivudine/Zidovudine |
|
| Legacy Concept Name |
Lamivudine_Zidovudine |
|
| Preferred_Name |
Lamivudine/Zidovudine |
|
| prefixIRI |
Thesaurus:C28939 |
|
| Semantic_Type |
Therapeutic or Preventive Procedure |
|
| UMLS_CUI |
C0717880 |
|
| subClassOf |