National Cancer Institute Thesaurus

Last uploaded: March 26, 2019
Preferred Name

Cefdinir

Synonyms

Cefdinir

CEFDINIR

Definitions

A semi-synthetic cephalosporin and a beta-lactam antibiotic with bactericidal activity. Cefdinir's effect is dependent on its binding to penicillin-binding proteins (PBPs) located in the bacterial cytoplasmic membrane. Binding results in the inhibition of the transpeptidase enzymes, thereby preventing cross-linking of the pentaglycine bridge with the fourth residue of the pentapeptide and interrupting consequent synthesis of peptidoglycan chains. As a result, cefdinir inhibits bacterial septum and cell wall synthesis formation.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28914

CAS_Registry

91832-40-5

CHEBI_ID

CHEBI:3485

Chemical_Formula

C14H13N5O5S2

code

C28914

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A semi-synthetic cephalosporin and a beta-lactam antibiotic with bactericidal activity. Cefdinir's effect is dependent on its binding to penicillin-binding proteins (PBPs) located in the bacterial cytoplasmic membrane. Binding results in the inhibition of the transpeptidase enzymes, thereby preventing cross-linking of the pentaglycine bridge with the fourth residue of the pentapeptide and interrupting consequent synthesis of peptidoglycan chains. As a result, cefdinir inhibits bacterial septum and cell wall synthesis formation.

FDA_UNII_Code

CI0FAO63WC

FULL_SYN

Cefdinir

CEFDINIR

label

Cefdinir

Legacy_Concept_Name

Cefdinir

Preferred_Name

Cefdinir

prefixIRI

ncit:C28914

Semantic_Type

Organic Chemical

Antibiotic

UMLS_CUI

C0060405

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C357

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http://purl.bioontology.org/ontology/NDDF/007588 NDDF LOOM
http://purl.bioontology.org/ontology/MESH/C056814 MESH LOOM
http://purl.jp/bio/4/id/200906070124780521 IOBC LOOM
http://purl.jp/bio/4/id/200906070124780521 IOBC LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/108677001 SNOMEDCT LOOM
http://stirdf.jst.go.jp/id/200907033648255093 IOBC LOOM
http://purl.bioontology.org/ontology/UATC/J01DD15 ATC LOOM
http://purl.obolibrary.org/obo/CHEBI_3485 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_3485 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_3485 GENEPIO LOOM
http://purl.obolibrary.org/obo/CHEBI_3485 NBO LOOM
http://purl.obolibrary.org/obo/CHEBI_3485 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_3485 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_3485 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_3485 CHEBI LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148556 NDFRT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C056814 RH-MESH LOOM
http://www.drugbank.ca/drugs/DB00535 FTC LOOM
http://purl.bioontology.org/ontology/VANDF/4021100 VANDF LOOM
http://purl.bioontology.org/ontology/LNC/MTHU011339 LOINC LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/370366006 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/LNC/LP19960-1 LOINC LOOM
http://purl.bioontology.org/ontology/RXNORM/25037 RXNORM LOOM