National Cancer Institute Thesaurus

Last uploaded: March 26, 2019
Preferred Name

Cefaclor

Synonyms

Cefaclor Hydrate

Cefaclor

CEFACLOR

Definitions

A beta-lactam, second-generation cephalosporin antibiotic with bactericidal activity. Cefaclor binds to and inactivates penicillin-binding proteins (PBP) located in bacterial cytoplasmic membranes. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28911

CAS_Registry

70356-03-5

Chemical_Formula

C15H14ClN3O4S.H2O

code

C28911

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A beta-lactam, second-generation cephalosporin antibiotic with bactericidal activity. Cefaclor binds to and inactivates penicillin-binding proteins (PBP) located in bacterial cytoplasmic membranes. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.

FDA_UNII_Code

69K7K19H4L

FULL_SYN

Cefaclor Hydrate

Cefaclor

CEFACLOR

label

Cefaclor

Legacy_Concept_Name

Cefaclor

Preferred_Name

Cefaclor

prefixIRI

ncit:C28911

Semantic_Type

Organic Chemical

Antibiotic

UMLS_CUI

C0007537

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C357

Delete Subject Author Type Created
No notes to display
Create New Mapping

Delete Mapping To Ontology Source
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D002433 RH-MESH LOOM
http://purl.bioontology.org/ontology/NDDF/002726 NDDF LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387270009 SNOMEDCT LOOM
http://stirdf.jst.go.jp/id/200907000428635167 IOBC LOOM
http://purl.bioontology.org/ontology/LNC/MTHU005577 LOINC LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/4937008 SNOMEDCT LOOM
http://www.co-ode.org/ontologies/galen#Cefaclor GALEN LOOM
http://purl.bioontology.org/ontology/VANDF/4017534 VANDF LOOM
http://purl.bioontology.org/ontology/UATC/J01DC04 ATC LOOM
http://purl.bioontology.org/ontology/MESH/D002433 MESH LOOM
http://purl.obolibrary.org/obo/CHEBI_3478 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_3478 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_3478 GENEPIO LOOM
http://purl.obolibrary.org/obo/CHEBI_3478 NBO LOOM
http://purl.obolibrary.org/obo/CHEBI_3478 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_3478 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_3478 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_3478 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_3478 NIFSTD LOOM
http://purl.bioontology.org/ontology/LNC/LP14176-9 LOINC LOOM
http://purl.bioontology.org/ontology/RXNORM/2176 RXNORM LOOM
http://purl.jp/bio/4/id/200906079766689339 IOBC LOOM
http://purl.jp/bio/4/id/200906079766689339 IOBC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.886.665.074.200.155 RH-MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D04.075.080.875.099.221.249.200.155 RH-MESH LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000145917 NDFRT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.065.589.099.249.200.155 RH-MESH LOOM
http://purl.bioontology.org/ontology/SNMI/C-53320 SNMI LOOM