loading...| Preferred Name |
Baclofen |
|
| Synonyms |
beta-(Aminomethyl)-4-chlorobenzenepropanoic Acid 4-Amino-3-(4-chlorophenyl)-butanoic Acid BA34647 BACLOFEN Baclofen Gablofen Kemstro Lioresal baclofen |
|
| Definitions |
A synthetic chlorophenyl-butanoic acid derivative used to treat spasms due to spinal cord damage and multiple sclerosis, muscle-relaxing Baclofen acts as a gamma-aminobutyric acid (GABA) agonist specific for GABA-B receptors. It acts at spinal and supraspinal sites, reducing excitatory transmission. (NCI04) |
|
| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28858 |
|
| Accepted_Therapeutic_Use_For |
Cerebral Spasticity, Chronic Spasticity |
|
| ALT_DEFINITION |
A drug that is used to treat certain types of muscle spasms and is being studied in the treatment of liver cancer. Baclofen relaxes muscles by blocking certain nerve receptors in the spinal cord. It is a type of antispasmodic. |
|
| CAS_Registry |
1134-47-0 |
|
| CHEBI_ID |
CHEBI:2972 |
|
| Chemical_Formula |
C10H12ClNO2 |
|
| code |
C28858 |
|
| Concept_In_Subset | ||
| Contributing_Source |
FDA |
|
| DEFINITION |
A synthetic chlorophenyl-butanoic acid derivative used to treat spasms due to spinal cord damage and multiple sclerosis, muscle-relaxing Baclofen acts as a gamma-aminobutyric acid (GABA) agonist specific for GABA-B receptors. It acts at spinal and supraspinal sites, reducing excitatory transmission. (NCI04) |
|
| FDA_UNII_Code |
H789N3FKE8 |
|
| FULL_SYN |
beta-(Aminomethyl)-4-chlorobenzenepropanoic Acid 4-Amino-3-(4-chlorophenyl)-butanoic Acid BA34647 BACLOFEN Baclofen Gablofen Kemstro Lioresal baclofen |
|
| Has_Salt_Form | ||
| label |
Baclofen |
|
| Legacy Concept Name |
Baclofen |
|
| NCI_Drug_Dictionary_ID |
560777 |
|
| NSC Number |
329137 |
|
| PDQ_Closed_Trial_Search_ID |
560777 |
|
| PDQ_Open_Trial_Search_ID |
560777 |
|
| Preferred_Name |
Baclofen |
|
| prefixIRI |
Thesaurus:C28858 |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0699999 |
|
| subClassOf |