Preferred Name |
Aztreonam |
|
Synonyms |
AZTREONAM Azactam Aztreonam SQ 26,776 |
|
Definitions |
A monocyclic beta-lactam antibiotic originally isolated from Chromobacterium violaceum with bactericidal activity. Aztreonam preferentially binds to and inactivates penicillin-binding protein-3 (PBP-3), which is involved in bacterial cell wall synthesis, thereby inhibiting bacterial cell wall integrity and leading to cell lysis and death. This agent differs from other beta-lactam antibiotics because it is resistant to beta-lactamase hydrolysis, and it is usually used to treat infections caused by gram-negative aerobic microorganisms. |
|
ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28845 |
|
CAS_Registry |
78110-38-0 |
|
CHEBI_ID |
CHEBI:161680 |
|
Chemical_Formula |
C13H17N5O8S2 |
|
code |
C28845 |
|
Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
|
Contributing_Source |
CTRP FDA |
|
DEFINITION |
A monocyclic beta-lactam antibiotic originally isolated from Chromobacterium violaceum with bactericidal activity. Aztreonam preferentially binds to and inactivates penicillin-binding protein-3 (PBP-3), which is involved in bacterial cell wall synthesis, thereby inhibiting bacterial cell wall integrity and leading to cell lysis and death. This agent differs from other beta-lactam antibiotics because it is resistant to beta-lactamase hydrolysis, and it is usually used to treat infections caused by gram-negative aerobic microorganisms. |
|
Display_Name |
Aztreonam |
|
FDA_UNII_Code |
G2B4VE5GH8 |
|
FULL_SYN |
AZTREONAM Azactam Aztreonam SQ 26,776 |
|
label |
Aztreonam |
|
Legacy Concept Name |
Aztreonam |
|
NCI_Drug_Dictionary_ID |
788184 |
|
NSC Number |
646279 |
|
PDQ_Closed_Trial_Search_ID |
788184 |
|
PDQ_Open_Trial_Search_ID |
788184 |
|
Preferred_Name |
Aztreonam |
|
prefixIRI |
Thesaurus:C28845 |
|
Semantic_Type |
Organic Chemical Pharmacologic Substance Antibiotic |
|
UMLS_CUI |
C0699281 |
|
subClassOf |