National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Aztreonam

Synonyms

AZTREONAM

Azactam

Aztreonam

SQ 26,776

Definitions

A monocyclic beta-lactam antibiotic originally isolated from Chromobacterium violaceum with bactericidal activity. Aztreonam preferentially binds to and inactivates penicillin-binding protein-3 (PBP-3), which is involved in bacterial cell wall synthesis, thereby inhibiting bacterial cell wall integrity and leading to cell lysis and death. This agent differs from other beta-lactam antibiotics because it is resistant to beta-lactamase hydrolysis, and it is usually used to treat infections caused by gram-negative aerobic microorganisms.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28845

CAS_Registry

78110-38-0

CHEBI_ID

CHEBI:161680

Chemical_Formula

C13H17N5O8S2

code

C28845

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

CTRP

FDA

DEFINITION

A monocyclic beta-lactam antibiotic originally isolated from Chromobacterium violaceum with bactericidal activity. Aztreonam preferentially binds to and inactivates penicillin-binding protein-3 (PBP-3), which is involved in bacterial cell wall synthesis, thereby inhibiting bacterial cell wall integrity and leading to cell lysis and death. This agent differs from other beta-lactam antibiotics because it is resistant to beta-lactamase hydrolysis, and it is usually used to treat infections caused by gram-negative aerobic microorganisms.

Display_Name

Aztreonam

FDA_UNII_Code

G2B4VE5GH8

FULL_SYN

AZTREONAM

Azactam

Aztreonam

SQ 26,776

label

Aztreonam

Legacy Concept Name

Aztreonam

NCI_Drug_Dictionary_ID

788184

NSC Number

646279

PDQ_Closed_Trial_Search_ID

788184

PDQ_Open_Trial_Search_ID

788184

Preferred_Name

Aztreonam

prefixIRI

Thesaurus:C28845

Semantic_Type

Organic Chemical

Pharmacologic Substance

Antibiotic

UMLS_CUI

C0699281

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C260

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Delete Mapping To Ontology Source
http://purl.bioontology.org/ontology/SNMI/C-53720 SNMI LOOM
http://purl.bioontology.org/ontology/LNC/LP16041-3 LOINC LOOM
http://purl.bioontology.org/ontology/RCD/e6f.. RCD LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D04.075.080.875.099.221.500.044 RH-MESH LOOM
http://www.phoc.org.cn/pmo/class/PMO_00015911 PMAPP-PMO LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#1644 OCHV LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D001398 RH-MESH LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000788184 PDQ LOOM
http://purl.obolibrary.org/obo/CHEBI_161680 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_161680 EUPATH LOOM
http://purl.obolibrary.org/obo/CHEBI_161680 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_161680 DOID LOOM
http://purl.obolibrary.org/obo/CHEBI_161680 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_161680 HHEAR LOOM
http://purl.obolibrary.org/obo/CHEBI_161680 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_161680 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_161680 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_161680 NIFSTD LOOM
http://purl.obolibrary.org/obo/CHEBI_161680 PHIPO LOOM
http://purl.obolibrary.org/obo/CHEBI_161680 GENEPIO LOOM
http://stirdf.jst.go.jp/id/200907073895397870 IOBC LOOM
http://purl.bioontology.org/ontology/LNC/MTHU006798 LOINC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.383.411.350.044 RH-MESH LOOM
http://purl.bioontology.org/ontology/MESH/D001398 MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.065.589.099.500.044 RH-MESH LOOM
http://purl.bioontology.org/ontology/NDDF/002807 NDDF LOOM
http://www.co-ode.org/ontologies/galen#Aztreonam GALEN LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146126 NDFRT LOOM
http://purl.bioontology.org/ontology/ATC/J01DF01 ATC LOOM
http://purl.bioontology.org/ontology/VANDF/4017762 VANDF LOOM
http://purl.obolibrary.org/obo/MESH_D001398 BERO LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387386004 SNOMEDCT LOOM
http://purl.obolibrary.org/obo/OMIT_0002774 OMIT LOOM
http://purl.bioontology.org/ontology/RXNORM/1272 RXNORM LOOM
http://purl.obolibrary.org/obo/ARO_3000550 ARO LOOM
http://purl.jp/bio/4/id/200906057545028482 IOBC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.886.108.500.044 RH-MESH LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0004521 OCHV LOOM
https://go.drugbank.com/drugs/DB00355 MDM LOOM
http://purl.obolibrary.org/obo/CHEBI_2960 NIFSTD LOOM
http://purl.obolibrary.org/obo/NCIT_C28845 BERO LOOM