National Cancer Institute Thesaurus

Last uploaded: February 4, 2019
Preferred Name

Anagrelide

Synonyms

anagrelide

Anagrelide

ANAGRELIDE

Definitions

A synthetic quinazoline derivative, Anagrelide reduces platelet production through a decrease in megakaryocyte maturation. Anagrelide inhibits cyclic AMP phosphodiesterase, as well as ADP- and collagen-induced platelet aggregation. At therapeutic doses, it does not influence white cell counts or coagulation parameters. Anagrelide is used for treatment of essential thrombocythemia to reduce elevated platelet counts and the risk of thrombosis. (NCI04)

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28825

ALT_DEFINITION

A drug that is used to decrease the number of platelets in the blood in order to prevent blood clotting.

CAS_Registry

68475-42-3

CHEBI_ID

CHEBI:142290

Chemical_Formula

C10H7Cl2N3O

code

C28825

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

Contributing_Source

FDA

DEFINITION

A synthetic quinazoline derivative, Anagrelide reduces platelet production through a decrease in megakaryocyte maturation. Anagrelide inhibits cyclic AMP phosphodiesterase, as well as ADP- and collagen-induced platelet aggregation. At therapeutic doses, it does not influence white cell counts or coagulation parameters. Anagrelide is used for treatment of essential thrombocythemia to reduce elevated platelet counts and the risk of thrombosis. (NCI04)

FDA_UNII_Code

K9X45X0051

FULL_SYN

anagrelide

Anagrelide

ANAGRELIDE

Has_Salt_Form

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28826

label

Anagrelide

Legacy_Concept_Name

Anagrelide

Preferred_Name

Anagrelide

prefixIRI

ncit:C28825

Semantic_Type

Pharmacologic Substance

Organic Chemical

UMLS_CUI

C0051809

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1327

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