loading...| Preferred Name |
Amantadine Hydrochloride |
|
| Synonyms |
AMANTADINE HYDROCHLORIDE Amantadine HCl amantadine hydrochloride Amantadine Hydrochloride Symmetrel |
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| Definitions |
The hydrochloride salt of amantadine, a synthetic tricyclic amine with antiviral, antiparkinsonian, and antihyperalgesic activities. Amantadine appears to exert its antiviral effect against the influenza A virus by interfering with the function of the transmembrane domain of the viral M2 protein, thereby preventing the release of infectious viral nucleic acids into host cells; furthermore, this agent prevents virus assembly during virus replication. Amantadine exerts its antiparkinsonian effects by stimulating the release of dopamine from striatal dopaminergic nerve terminals and inhibiting its pre-synaptic reuptake. This agent may also exert some anticholinergic effect through inhibition of N-methyl-D-aspartic acid (NMDA) receptor-mediated stimulation of acetylcholine, resulting in antihyperalgesia. |
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| ID |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28818 |
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| Accepted_Therapeutic_Use_For |
Parkinson disease; infections caused by influenza A virus |
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| ALT_DEFINITION |
A drug used to treat infections caused by the influenza A virus. It blocks the ability of the virus to infect cells and to make more virus particles. It is also used to treat the symptoms of Parkinson disease. Amantidine hydrochloride is a type of antiviral agent. |
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| CAS_Registry |
665-66-7 |
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| CHEBI_ID |
CHEBI:2619 |
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| Chemical_Formula |
C10H17N.ClH |
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| code |
C28818 |
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| Concept_In_Subset |
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424 http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978 |
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| Contributing_Source |
CTRP FDA |
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| DEFINITION |
The hydrochloride salt of amantadine, a synthetic tricyclic amine with antiviral, antiparkinsonian, and antihyperalgesic activities. Amantadine appears to exert its antiviral effect against the influenza A virus by interfering with the function of the transmembrane domain of the viral M2 protein, thereby preventing the release of infectious viral nucleic acids into host cells; furthermore, this agent prevents virus assembly during virus replication. Amantadine exerts its antiparkinsonian effects by stimulating the release of dopamine from striatal dopaminergic nerve terminals and inhibiting its pre-synaptic reuptake. This agent may also exert some anticholinergic effect through inhibition of N-methyl-D-aspartic acid (NMDA) receptor-mediated stimulation of acetylcholine, resulting in antihyperalgesia. |
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| Display_Name |
Amantadine Hydrochloride |
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| FDA_UNII_Code |
M6Q1EO9TD0 |
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| FULL_SYN |
AMANTADINE HYDROCHLORIDE Amantadine HCl amantadine hydrochloride Amantadine Hydrochloride Symmetrel |
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| Has_Free_Acid_Or_Base_Form | ||
| label |
Amantadine Hydrochloride |
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| Legacy Concept Name |
Amantadine_Hydrochloride |
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| NCI_Drug_Dictionary_ID |
471831 |
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| NSC Number |
83653 |
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| PDQ_Closed_Trial_Search_ID |
471831 |
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| PDQ_Open_Trial_Search_ID |
471831 |
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| Preferred_Name |
Amantadine Hydrochloride |
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| prefixIRI |
Thesaurus:C28818 |
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| Semantic_Type |
Organic Chemical Pharmacologic Substance |
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| UMLS_CUI |
C0723562 |
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| subClassOf |