National Cancer Institute Thesaurus

Last uploaded: February 23, 2024
Preferred Name

Asparaginase

Synonyms

L-asparaginase

asparaginase

L-Asparagine Amidohydrolase

Asparaginase II

Asparaginase

L-Asparaginase

Re-82-TAD-15

L-Asparagine amidohydrolase

Asparaginase-E.Coli

ASPARAGINASE

ASP-1

Colaspase

Elspar

Kidrolase

L-ASP

L-Asnase

Laspar

Lcf-ASP

Leucogen

Leunase

MK-965

Paronal

Serasa

Spectrila

Definitions

An enzyme isolated from the bacterium Escherichia coli or the bacterium Erwinia carotovora with antileukemic activity. Asparaginase hydrolyzes L-asparagine to L-aspartic acid and ammonia in leukemic cells, resulting in the depletion of asparagine, inhibition of protein synthesis, cell cycle arrest in the G1 phase, and apoptosis in susceptible leukemic cell populations. Asparagine is critical to protein synthesis in leukemic cells; some leukemic cells cannot synthesize this amino acid de novo due to the absent or deficient expression of the enzyme asparagine synthase. The E. carotovora-derived form of asparaginase is typically reserved for cases of asparaginase hypersensitivity.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C286

Accepted_Therapeutic_Use_For

Acute lymphocytic leukemia; Acute non-lymphocytic leukemia

ALT_DEFINITION

A drug that is used to treat acute lymphoblastic leukemia (ALL) and is being studied in the treatment of some other types of cancer. It is an enzyme taken from the bacterium Escherichia coli (E. coli). It breaks down the amino acid asparagine and may block the growth of tumor cells that need asparagine to grow.

CAS_Registry

9015-68-3

code

C286

Concept_In_Subset

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C176424

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157711

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C157712

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116978

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C201600

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C142799

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C116977

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C128784

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177537

Contributing_Source

CTRP

FDA

GDC

HemOnc

DEFINITION

An enzyme isolated from the bacterium Escherichia coli or the bacterium Erwinia carotovora with antileukemic activity. Asparaginase hydrolyzes L-asparagine to L-aspartic acid and ammonia in leukemic cells, resulting in the depletion of asparagine, inhibition of protein synthesis, cell cycle arrest in the G1 phase, and apoptosis in susceptible leukemic cell populations. Asparagine is critical to protein synthesis in leukemic cells; some leukemic cells cannot synthesize this amino acid de novo due to the absent or deficient expression of the enzyme asparagine synthase. The E. carotovora-derived form of asparaginase is typically reserved for cases of asparaginase hypersensitivity.

Display_Name

Asparaginase

FDA_UNII_Code

G4FQ3CKY5R

FULL_SYN

L-asparaginase

asparaginase

L-Asparagine Amidohydrolase

Asparaginase II

Asparaginase

L-Asparaginase

Re-82-TAD-15

L-Asparagine amidohydrolase

Asparaginase-E.Coli

ASPARAGINASE

ASP-1

Colaspase

Elspar

Kidrolase

L-ASP

L-Asnase

Laspar

Lcf-ASP

Leucogen

Leunase

MK-965

Paronal

Serasa

Spectrila

Has_Target

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29607

Is_Value_For_GDC_Property

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1909

label

Asparaginase

Legacy Concept Name

Asparaginase

Maps_To

Asparaginase

NCI_Drug_Dictionary_ID

41146

NSC Number

109229

PDQ_Closed_Trial_Search_ID

41146

PDQ_Open_Trial_Search_ID

41146

Preferred_Name

Asparaginase

prefixIRI

Thesaurus:C286

Semantic_Type

Pharmacologic Substance

Enzyme

UMLS_CUI

C0003993

subClassOf

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C177280

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